| Autor: |
Yeo J; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Tassone JP; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Ellman JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2024 Nov 15; Vol. 26 (45), pp. 9769-9774. Date of Electronic Publication: 2024 Oct 31. |
| DOI: |
10.1021/acs.orglett.4c03740 |
| Abstrakt: |
The synthesis of sterically congested amides was accomplished via Cp*Co(III)-catalyzed sequential C-H bond addition to 1,3-dienes followed by aminocarbonylation with isocyanates, a coupling partner that had never been utilized in sequential C-H bond addition reactions. A variety of C-H bond reactants, internally substituted dienes, and aromatic isocyanates provided secondary amide products incorporating α-all-carbon quaternary centers. The conversion of the amide products to other useful compound classes was also demonstrated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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