[Analysis of Frequencies and Subsets of Peripheral Helper T Cells in Patients with Immune Thrombocytopenia].
| Autor: | Li WP; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044， Liaoning Province, China.; Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China., Bai ZR; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044， Liaoning Province, China., Tian YQ; Department of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China., Yin CL; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044， Liaoning Province, China., Li X; Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044， Liaoning Province, China. |
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| Jazyk: | čínština |
| Zdroj: | Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2024 Oct; Vol. 32 (5), pp. 1518-1523. |
| DOI: | 10.19746/j.cnki.issn.1009-2137.2024.05.033 |
| Abstrakt: | Objective: To investigate the frequencies and subset distribution of peripheral helper (Tph) T cells in patients with immune thrombocytopenia (ITP), and explore the pathogenesis of ITP. Methods: A total of 25 newly diagnosed ITP patients treated in The Second Affiliated Hospital of Dalian Medical University from January to December 2022 were selected, and 25 healthy volunteers (age- and sex-matched) were recruited as the control group. Flow cytometry was used to detect the subsets of CD4 + T cells and Tph cells. Results: The frequency of effector memory (CCR7 - CD45RO + CD4 + ) T cells in ITP patients was significantly higher than that in healthy controls( P < 0.05). The frequency of Tph cells in ITP patients was also significantly higher than that in healthy controls ( P < 0.001), and most of the Tph cells in ITP patients were effector memory T cells. Furthermore, the expressions of T-cell costimulatory molecules in Tph cells, including ICOS and CD84, were similar to those in follicular helper T(Tfh) cells. CXCR3 - CCR6 - Tph (Tph2) subgroup was dominant in Tph cells, but the frequency of CXCR3 + CCR6 - Tph (Tph1) cells in ITP patients was much higher than that in healthy controls ( P < 0.05). Conclusion: Tph cells, especially Tph1 cells, were abnormally expanded in ITP patients, which may be a potential etiology of ITP. |
| Databáze: | MEDLINE |
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