Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults.

Autor: Bernal J; Institute of Cognitive Neurology and Dementia Research, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany. jose.bernalmoyano@dzne.de.; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. jose.bernalmoyano@dzne.de.; Centre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh, UK. jose.bernalmoyano@dzne.de.; UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, UK. jose.bernalmoyano@dzne.de., Menze I; Institute of Cognitive Neurology and Dementia Research, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Yakupov R; Institute of Cognitive Neurology and Dementia Research, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Peters O; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Hellmann-Regen J; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, Department of Psychiatry and Neurosciences, Campus Benjamin Franklin, Berlin, Germany.; German Centre for Mental Health (DZPG), Berlin, Germany., Freiesleben SD; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, Berlin, Germany., Priller J; UK Dementia Research Institute Centre at the University of Edinburgh, Edinburgh, UK.; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany.; School of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, Munich, Germany., Spruth EJ; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Altenstein S; German Centre for Neurodegenerative Diseases (DZNE), Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité, Berlin, Germany., Schneider A; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Fliessbach K; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn and University of Bonn, Bonn, Germany., Wiltfang J; German Centre for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Centre Göttingen, University of Göttingen, Göttingen, Germany.; Neurosciences and Signalling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Schott BH; German Centre for Neurodegenerative Diseases (DZNE), Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Centre Göttingen, University of Göttingen, Göttingen, Germany.; Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118, Magdeburg, Germany., Jessen F; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.; Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Rostamzadeh A; Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany., Glanz W; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Incesoy EI; Institute of Cognitive Neurology and Dementia Research, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, Magdeburg, Germany., Buerger K; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Janowitz D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Ewers M; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany., Perneczky R; German Centre for Neurodegenerative Diseases (DZNE), Munich, Germany.; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy) Munich, Munich, Germany.; Ageing Epidemiology Research Unit (AGE), School of Public Health, Imperial College London, London, UK., Rauchmann BS; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.; Department of Neuroradiology, University Hospital LMU, Munich, Germany., Teipel S; German Centre for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Centre, Rostock, Germany., Kilimann I; German Centre for Neurodegenerative Diseases (DZNE), Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Centre, Rostock, Germany., Laske C; German Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Sodenkamp S; German Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Spottke A; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, University of Bonn, Bonn, Germany., Esser A; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany., Lüsebrink F; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Dechent P; Department of Cognitive Neurology, MR-Research in Neurosciences, Georg-August-University, Göttingen, Germany., Hetzer S; Berlin Centre for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany., Schreiber S; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Department of Neurology, University Hospital Magdeburg, Magdeburg, Germany., Düzel E; Institute of Cognitive Neurology and Dementia Research, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Ziegler G; Institute of Cognitive Neurology and Dementia Research, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; German Centre for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Jazyk: angličtina
Zdroj: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Oct 28; Vol. 16 (1), pp. 240. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1186/s13195-024-01606-5
Abstrakt: Background: For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussions about their coupled temporal dynamics. Longitudinal studies supporting this hypothesis nonetheless remain scarce.
Methods: We applied global and regional bivariate latent growth curve modelling to determine the extent to which WMH and cortical thickness were interrelated over a four-year period. For this purpose, we leveraged longitudinal MRI data from 451 cognitively unimpaired participants (DELCODE; median age 69.71 [IQR 65.51, 75.50] years; 52.32% female). Participants underwent MRI sessions annually over a four-year period (1815 sessions in total, with roughly four MRI sessions per participant). We adjusted all models for demographics and cardiovascular risk.
Results: Our findings were three-fold. First, larger WMH volumes were linked to lower cortical thickness (σ = -0.165, SE = 0.047, Z = -3.515, P < 0.001). Second, individuals with higher WMH volumes experienced more rapid cortical thinning (σ = -0.226, SE = 0.093, Z = -2.443, P = 0.007), particularly in temporal, cingulate, and insular regions. Similarly, those with lower initial cortical thickness had faster WMH progression (σ = -0.141, SE = 0.060, Z = -2.336, P = 0.009), with this effect being most pronounced in temporal, cingulate, and insular cortices. Third, faster WMH progression was associated with accelerated cortical thinning (σ = -0.239, SE = 0.139, Z = -1.710, P = 0.044), particularly in frontal, occipital, and insular cortical regions.
Conclusions: Our study suggests that cortical thinning and WMH progression could be mutually reinforcing rather than parallel, unrelated processes, which become entangled before cognitive deficits are detectable.
Trial Registration: German Clinical Trials Register (DRKS00007966, 04/05/2015).
(© 2024. The Author(s).)
Databáze: MEDLINE
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