Analysis of Angiographic Patterns in Acute Coronary Syndrome Patients With Diabetes Mellitus: Correlation With HbA1c Levels.

Autor:	Garg Y; Endocrinology Diabetes Medicine, Samatvam Diabetes Endocrinology and Medical Center, Bangalore, IND., Marthandam Manickandan AP; Internal Medicine, Central America Health Sciences University Belize Medical College, Ladyville, BLZ., Ghori HK; Internal Medicine, JSS Medical College, Mysore, IND., Rameshbabu S; Internal Medicine, Madras Medical College, Chennai, IND., Mohammed I; Internal Medicine, Shadan Institute of Medical Sciences, Chennai, IND., Mohamed S; Internal Medicine, Mysore Medical College, Mysore, IND., Mustafa Chiniwala H; Medicine, Sahyadri Hospital Hadapsar, Chennai, IND., Mohamed S; Psychiatry, Kanachur Institute of Medical Sciences, Mangalore, IND., Doshi B; Community and Family Medicine, Swaminarayan Institute of Medical Science and PSM Hospital, Kalol, IND., Pascal S; Community Medicine, Madha Medical College and Research Institute, Chennai, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 21; Vol. 16 (10), pp. e72028. Date of Electronic Publication: 2024 Oct 21 (Print Publication: 2024).
DOI:	10.7759/cureus.72028
Abstrakt:	Background The relation of diabetes mellitus with cardiovascular diseases is well-known, even acute coronary syndrome (ACS). High levels of glycated haemoglobin (HbA1c) are used is a sign of long-term glycemic control and may be associated with severity in coronary artery disease (CAD). In this particular setting, the aim of this investigation was to examine the relationship between the HbA1c values and the angiographic patterns of patients who were admitted with an ACS diagnosis. Methodology A cross-sectional study included 120 patients diagnosed with ACS. The criteria for eligibility included patients with ST-elevation myocardial infarction, unstable angina, and non-ST elevation myocardial infarction with history of documented diabetes mellitus. Every patient had a suitable clinical examination, had their HbA1c checked, and had coronary angiography to determine the severity of their CAD. Descriptive statistics and ANOVA were performed for statistical analyses to determine the connection between angiographic patterns and HbA1c. Results Patients with elevated HbA1c levels demonstrated a strong association with severe coronary artery disease. Notably, those with HbA1c exceeding 10.5% exhibited significant triple vessel disease and Type C lesions, indicative of advanced coronary artery disease. Statistical analyses revealed a marked difference in angiographic patterns across various HbA1c categories (p < 0.05). Conclusion The findings of this study suggest that maintaining optimal HbA1c levels is essential for mitigating the severity of coronary artery disease in patients with ACS. Moreover, effective glycemic control may be protective against advanced coronary atherosclerosis and subsequent cardiovascular complications in both diabetic and non-diabetic individuals. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Madha Medical College and Research Institute issued approval MMCRI/IEC/2022/027. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Garg et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu