| Autor: |
Wang F; Department of Oral Medicine, The Third Hospital of Hebei Medical University., Wang J; Department of Oral Pathology, Hospital of Stomatology Hebei Medical University., Zhang L; Department of Clinical Laboratory, The Third Hospital of Hebei Medical University., Fan S; Department of Oral Medicine, The Third Hospital of Hebei Medical University., Liu S; Department of Stomatology, Tangshan People's Hospital. |
| Jazyk: |
angličtina |
| Zdroj: |
Dental materials journal [Dent Mater J] 2024 Dec 10; Vol. 43 (6), pp. 842-849. Date of Electronic Publication: 2024 Oct 26. |
| DOI: |
10.4012/dmj.2024-007 |
| Abstrakt: |
This study investigated the impact of combining human umbilical cord mesenchymal stem cells (hUC-MSCs) with concentrated growth factor (CGF) on regenerating necrotic pulp. Ten-month-old male Bama miniature pigs were divided into control and caries groups. The experimental teeth were randomly divided into three groups: caries untreated, Ca(OH) 2 , and engineering dental pulp-like tissue (EDPT). hUC-MSCs and CGF scaffold were combined to construct EDPT, and the histological structure was observed. Odontoblasts and dental pulp cells were counted in each group. The results showed that hUC-MSCs adhered firmly to the porous mesh CGF scaffold, grew vigorously, and stretched sufficiently. In the EDPT group, odontoblasts in the root canal were arranged neatly, and predentin was formed. The odontoblast and dental pulp cell counts in the EDPT group were statistically significant compared to the caries untreated and Ca(OH) 2 groups. The hUC-MSCs-CGF could successfully repair necrotic pulp in animals with dental caries. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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