An innovative electrical neurostimulation approach to mimic reflexive urination control in spinal cord injury models.

Autor: Li J; School of Physical Science and Technology, Guangxi University, Nanning, 530004, China., Deng G; Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, 200052, China., Li X; Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, 200052, China., Yin L; Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, 530004, China., Yuan C; Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, 200052, China., Shao W; Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, 530004, China., Chen Y; Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, 200052, China. orthodoctchen@163.com., Yao J; Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, 200052, China. moerfusi@126.com.; Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing, 400030, China. moerfusi@126.com., Yan J; School of Physical Science and Technology, Guangxi University, Nanning, 530004, China. junan_yan@aliyun.com.; Department of Urology, PLA Naval Medical Center, Naval Medical University, Shanghai, 200052, China. junan_yan@aliyun.com.; Department of Urology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. junan_yan@aliyun.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 25; Vol. 14 (1), pp. 25305. Date of Electronic Publication: 2024 Oct 25.
DOI: 10.1038/s41598-024-76499-3
Abstrakt: Neurogenic lower urinary tract dysfunction (NLUTD) is a frequent consequence of spinal cord injury (SCI), leading to symptoms that significantly impact quality of life. Although many life-saving techniques are available, current treatment strategies for managing NLUTD still exhibit limitations and drawbacks. Here, we introduce a new electrical neuromodulation strategy involving electrical stimulation of the major pelvic ganglion (MPG) to initiate bladder contraction, in conjunction with innovative programmable (IPG) electrical stimulation on the pudendal nerve (PN) to induce external urethral sphincter (EUS) relaxation in freely moving or anesthetized SCI mice. Furthermore, we conducted the void spot assay, and cystometry coupled with EUS electromyography (EMG) recordings to evaluate voiding function, and monitor bladder pressure and EUS activity. Our findings demonstrate that our novel electrical neuromodulation approach effectively triggers coordinated bladder muscle contraction and EUS relaxation, effectively counteracting SCI-induced NLUTD. Additionally, this electrical neuromodulation method enhances voiding efficiency, closely resembling natural reflexive urination in SCI mice. Thus, our study offers a promising electrical neurostimulation approach aimed at restoring physiological coordination and potentially offering personalized treatment for improving voiding efficiency in individuals with SCI-associated NLUTD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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