Diagnostic Performances of 18 F-Fluorocholine PET/CT as First-Line Functional Imaging Method for Localization of Hyperfunctioning Parathyroid Tissue in Primary Hyperparathyroidism.

Autor:	Bouilloux E; Nuclear Medicine Department, Centre Georges François Leclerc, 21000 Dijon, France., Santucci N; Endocrine Surgery Department, University Hospital François Mitterand, 21000 DIjon, France., Bertaut A; Biostatistics and Methodology Department, Centre Georges François Leclerc, 21000 Dijon, France., Alberini JL; Nuclear Medicine Department, Centre Georges François Leclerc, 21000 Dijon, France; ICMUB UMR CNRS 6302, 21000 Dijon, France., Cochet A; Nuclear Medicine Department, Centre Georges François Leclerc, 21000 Dijon, France; ICMUB UMR CNRS 6302, 21000 Dijon, France., Drouet C; Nuclear Medicine Department, Centre Georges François Leclerc, 21000 Dijon, France. Electronic address: cldrouet@cgfl.fr.
Jazyk:	angličtina
Zdroj:	Academic radiology [Acad Radiol] 2024 Oct 24. Date of Electronic Publication: 2024 Oct 24.
DOI:	10.1016/j.acra.2024.10.013
Abstrakt:	Rationale and Objectives: This study evaluated the diagnostic performance of 18 F-fluorocholine (FCH) PET/CT as the first-line functional imaging method for preoperative localization of hyperfunctioning parathyroid glands (HPGs) in patients with primary hyperparathyroidism (PHPT). Materials and Methods: This retrospective single-center study included 80 consecutive patients with PHPT, referred for FCH PET/CT between January 2018 and July 2022, and who subsequently underwent surgery. The diagnostic performance of FCH PET/CT was compared to histological results for per-lesion analysis, and to postoperative resolution of biochemical PHPT for per-patient analysis. Results: 18 F-FCH-PET/CT revealed 95 positive foci in 77/80 patients and was negative in 3/80 patients. Postoperative resolution of HPT was obtained in 67/80 patients (84%). Per-lesion analysis showed 80 true positives, five true negatives, 11 false negatives, and eight false positives. Seven PET-positive foci could not be compared to histology. In a first per-lesion analysis, excluding these seven anomalies, sensitivity and positive predictive value (PPV) of FCH PET/CT were 88% (95% CI: 79-94) and 91% (95% CI: 87-94), respectively. In a second per-lesion analysis considering the seven anomalies as false positives (maximum bias analysis), PPV was 84% (95% CI: 80%-87%). By per-patient analysis, FCH PET/CT correctly identified and located all pathological glands in 56/80 (70%, 95% CI: 59-80) patients. Conclusion: 18 F-Fluorocholine PET/CT appears to be an effective pre-surgical imaging method for localization of hyperfunctioning parathyroid tissue in patients with PHPT. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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