Associations of exposure to PM 2.5 and its compounds with carotid intima-media thickness among middle-aged adults.
Autor: | Kim K; Department of Social and Preventive Medicine, Sungkyunkwan University School of Medicine, South Korea; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Yao J; Department of Epidemiology and Biostatistics, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA., Jacobs DR Jr; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Martin RV; Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, MO, USA., van Donkelaar A; Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, MO, USA., Su WC; Department of Environmental Science, Baylor University, Waco, TX, USA., Zhang C; Center for Cancer and Immunology Research, Children's National Medical Center/Children's National Research Institute, Department of Pediatrics, George Washington University, Washington, DC, USA., Chen X; Department of Geography, Sustainability, Community and Urban Studies, University of Connecticut, Storrs, CT, USA., Murthy VL; Department of Medicine and Radiology, University of Michigan, Ann Arbor, MI, USA., Zhang X; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Yale University School of Nursing, Orange, CT, USA., Lloyd-Jones D; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhang K; Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address: kzhang9@albany.edu. |
---|---|
Jazyk: | angličtina |
Zdroj: | The Science of the total environment [Sci Total Environ] 2024 Dec 10; Vol. 955, pp. 177098. Date of Electronic Publication: 2024 Oct 31. |
DOI: | 10.1016/j.scitotenv.2024.177098 |
Abstrakt: | Background: Exposure to fine particulate matter (PM Methods: In this cross-sectional study, we included 3257 participants (aged 37-51 years) from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Exposure to PM Results: Greater exposure to BC was associated with higher cIMT (mm) (β =0.034, 95 % CI = 0.019-0.049, per IQR increase [0.56 μg/m 3 ] of BC) among participants with a mean age of 45.0, consisting of 45.9 % Black and 54.1 % White males and females. The association was generally consistent across participants' demographic characteristics. In our BKMR analysis, BC exhibited a dose-response association with cIMT with a high contribution to the association of cIMT with PM Conclusions: Our findings suggest that certain compounds of PM Competing Interests: Declaration of competing interest V. Murthy owns stock in General Electric, Cardinal Health, Viatris, Pfizer, Amgen, Merck and Johnson & Johnson and stock options in Ionetix. He is a paid consultant for INVIA Medical Imaging Solutions & Siemens Healthineers. V. Murthy has received research support through his institution from Siemens Healthineers. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |