| Autor: |
Ganipineni VDP; Department of Medicine, Andhra Medical College, Visakhapatnam 530002, India., Jitta SR; Department of Internal Medicine, Mercy Hospital, Saint Louis, MO 63141, USA., Gudiwada MCVB; Department of Internal Medicine, University of Nebraska Medical Center, Chicago, IL 60657, USA., Jasti JR; Department of Internal Medicine, University of South Dakota, Sioux Falls, SD 57108, USA., Janga C; Department of Internal Medicine, Jefferson Abington Hospital, Abington, PA 19001, USA., Merugu B; Department of Medicine, MediCiti Institute of Medical Science, Hyderabad 501401, India., Bandaru RR; Department of Internal Medicine, East Carolina University, Greenville, NC 27834, USA., Puli S; Department of Hospital Medicine, Cheshire Medical Center, Keene, NH 03431, USA., Venkata VS; Department of Hospital Medicine, Cheshire Medical Center, Keene, NH 03431, USA., Vasavada A; Department of Family Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA., Desai R; Independent Researcher, Atlanta, GA 30079, USA. |
| Abstrakt: |
Background: Pulmonary hypertension (PH) can lead to cardiac failure, thereby significantly affecting life expectancy and quality of life. Due to inadequate disease surveillance and risk assessment, clinical challenges persist despite advances in diagnosis and treatment. We aimed to review the potential of high-sensitivity cardiac troponin (hs-cTn) as a biomarker for predicting outcomes in PH patients. Methods: A thorough examination of the PubMed and Google Scholar databases was conducted through March 2023. Studies involving adult PH patients and hsTn as a prognostic indicator of outcomes such as mortality, hospitalization, and disease progression were included, after screening their titles and abstracts. Two independent evaluators extracted data, with the quality assessed using the JBI critical appraisal tool. Results: This review uncovered eight studies that examined the prognostic value of hs-cTn in PH patients. Higher hs-cTn levels were associated with increased mortality and hospitalization rates, according to the studies. The severity of PH, cardiac dysfunction, right ventricular function, and systolic dysfunction were associated with hs-cTn. Multiple studies have demonstrated that hsTn has the potential to identify high-risk PH patients who could benefit from targeted therapies and increased clinical monitoring. Conclusions: This review suggests that hsTn may be a biomarker for PH risk stratification and prognosis. Across PH subtypes, elevated hsTn levels predict poor outcomes. However, large-scale prospective studies are needed to confirm hs-cTn's function in diagnosing pulmonary hypertension and determine its potential value in treatment. |
