Automated planning of curved needle channels in 3D printed patient-tailored applicators for cervical cancer brachytherapy.
| Autor: | Straathof R; Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands.; Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands., van Vliet-Pérez SM; Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands.; Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Kolkman-Deurloo IK; Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Wauben LSGL; Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands., Nout RA; Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Heijmen BJM; Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Rossi L; Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Dankelman J; Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands., van de Berg NJ; Department of BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands.; Department of Gynaecological Oncology, Erasmus MC Cancer Institute, University Medical Centre Rotterdam, Rotterdam, The Netherlands. |
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| Jazyk: | angličtina |
| Zdroj: | Physics in medicine and biology [Phys Med Biol] 2024 Nov 25; Vol. 69 (23). Date of Electronic Publication: 2024 Nov 25. |
| DOI: | 10.1088/1361-6560/ad8b08 |
| Abstrakt: | Purpose. Patient-tailored intracavitary/interstitial (IC/IS) brachytherapy (BT) applicators may increase dose conformity in cervical cancer patients. Current configuration planning methods in these custom applicators rely on manual specification or a small set of (straight) needles. This work introduces and validates a two-stage approach for establishing channel configurations in the 3D printed patient-tailored ARCHITECT applicator. Methods. For each patient, the patient-tailored applicator shape was based on the first BT application with a commercial applicator and integrated connectors to a commercial (Geneva) intrauterine tube and two lunar ring channels. First, a large candidate set was generated of channels that steer the needle to desired poses in the target region and are contained in the applicator. The channels' centrelines were represented by Bézier curves. Channels running between straight target segments and entry points were optimised and refined to ensure (dynamic) feasibility. Second, channel configurations were selected using geometric coverage optimisation. This workflow was applied to establish patient-tailored geometries for twenty-two patients previously treated using the Venezia applicator. Treatment plans were automatically generated using the in-house developed algorithm BiCycle. Plans for the clinically used configuration,TPclin, and patient-tailored configuration,TParch, were compared. Results. Channel configurations could be generated in clinically feasible time (median: 2651 s, range 1826-3812 s). AllTParchandTPclinplans were acceptable, but planning aims were more frequently attained with patient-tailored configurations (115/132 versus 100/132 instances). Median CTV (Creative Commons Attribution license.) |
| Databáze: | MEDLINE |
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