Insights into disease resilience and longevity: Hints from COVID-19 recovered nonagenarians and centenarians.

Autor: de Castro MV; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Sábato C; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Dandalo-Girardi RM; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Silva MVR; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Dell'Aquila LP; Prevent Senior Institute, São Paulo, São Paulo, Brazil., Razuk-Filho Á; Prevent Senior Institute, São Paulo, São Paulo, Brazil., Batista-Júnior PB; Prevent Senior Institute, São Paulo, São Paulo, Brazil., Naslavsky MS; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Zatz M; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil. Electronic address: mayazatz@usp.br.
Jazyk: angličtina
Zdroj: Gene [Gene] 2025 Jan 20; Vol. 934, pp. 149025. Date of Electronic Publication: 2024 Oct 20.
DOI: 10.1016/j.gene.2024.149025
Abstrakt: The effects of aging on the organism manifest in various ways, including profound and complex changes in functioning patterns, responses to stimuli, and regenerative capacity. Nevertheless, it is remarkable that some elderly individuals maintain their health and functionality despite advanced age, showing resilience to environmental adversities, such as SARS-CoV-2 infection. In this study, we examined a unique cohort of 100 individuals older than 90 years, including centenarians, who recovered from COVID-19 before the availability of vaccines in Brazil. We performed whole-exome analyses and identified incidental findings in four participants. These findings included pathogenic variants associated with serious conditions, such as cancer predisposition and cardiovascular diseases. Specifically, variants were found in the RYR1, DSP, BRCA2, BRCA1, and TTN genes. Also, other two individuals were homozygous for rare variants in the TYK2 gene, related to primary immunodeficiencies. The significance of these findings is underscored by the fact that, despite carrying these rare variants, these individuals surpassed 90 years of age and survived the COVID-19 pandemic. This suggests the presence of genetic protective factors that contribute to longevity and resilience. Therefore, this study provides new insights into interpreting incidental findings in long-lived populations and raises important questions for clinical practice and the genetics of longevity.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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