Design of thermally programmable 3D shape memory polymer-based devices tailored for endovascular treatment of intracranial aneurysms.

Autor: Das R; Department of Bioengineering, University of California Riverside, Riverside, CA, USA., Cabaniss TL; School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK, USA., Pineda-Castillo SA; Stephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA., Bohnstedt BN; Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA., Liu Y; Stephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA., Lee CH; Department of Bioengineering, University of California Riverside, Riverside, CA, USA; Stephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA. Electronic address: chunghal@ucr.edu.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Dec; Vol. 160, pp. 106784. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1016/j.jmbbm.2024.106784
Abstrakt: Despite recent technological advancements in endovascular embolization devices for treating intracranial aneurysms (ICAs), incomplete occlusion and aneurysm recanalization remain critical challenges. Shape memory polymer (SMP)-based devices, which can be manufactured and tailored to patient-specific aneurysm geometries, possess the potential to overcome the suboptimal treatment outcome of the gold standard: endovascular coiling. In this work, we propose a highly porous patient-specific SMP embolic device fabricated via 3D printing to optimize aneurysm occlusion, and thus, improve the long-term efficacy of endovascular treatment. To facilitate device deployment at the aneurysm via Joule-heating, we introduce a stable, homogeneous coating of poly-pyrrole (PPy) to enhance the electrical conductivity in the SMP material. Using an in-house pulse width modulation circuit, we induced Joule-heating and characterized the shape recovery of the PPy-coated SMP embolic devices. We found that the employed PPy coating enables enhanced electrical and thermal conductivity while only slightly altering the glass transition temperature of the SMP material. Additionally, from a series of parametric studies, we identified the combination of catalyst concentration and pyrrole polymerization time that yielded the shape recovery properties ideal for ICA endovascular therapy. Collectively, these findings highlight a promising material coating for a future coil-free, personalized shape memory polymer (SMP) embolic device, designed to achieve long-lasting, complete occlusion of aneurysms.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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