[The use of alginate plates with a complex of antimicrobial peptides and cytokines after surgical interventions on periodontal tissues as a prevention of early postoperative complications].

Autor:	Brizgalova VA; Russian University of Medicine, Moscow, Russia.; A.I. Evdokimov Scientific and Educational Center of Dentistry, Moscow, Russia., Runova GS; Russian University of Medicine, Moscow, Russia., Revazova ZE; A.I. Evdokimov Scientific and Educational Center of Dentistry, Moscow, Russia., Lalieva ZE; A.I. Evdokimov Scientific and Educational Center of Dentistry, Moscow, Russia., Dorzhieva MY; Russian University of Medicine, Moscow, Russia., Babanina AA; Russian University of Medicine, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Stomatologiia [Stomatologiia (Mosk)] 2024; Vol. 103 (5), pp. 19-23.
DOI:	10.17116/stomat202410305119
Abstrakt:	Objective: To evaluate the possibility of improving the effectiveness of early postoperative healing in patients after surgical interventions on periodontal tissues due to the topical application of alginate plates with a complex of antimicrobial peptides and cytokines. Materials and Methods: 40 patients who underwent periodontal surgery were examined: operations aimed at bone tissue regeneration; mucogingival operations (elimination of gum recession), corticotomy with osteoplasty, apical surgery. The patients were randomly divided into 2 groups of 20 people (main and control). At the end of the operation, alginate plates with a complex of antimicrobial peptides and cytokines were applied to the surgical intervention area to the main group. Further, 2-3 times a day, it was recommended to apply them independently for 10-14 days, after antiseptic treatment. In the control group, they were limited to double treatment with 0.05% chlorhexidine bigluconate solution daily for two weeks. Follow-up examinations and evaluation of the index of early wound healing, as well as indicators of postoperative pain, bleeding and edema were carried out on day 3, 7, 14. Results: In all patients in the early postoperative period, positive dynamics of healing were observed, however, in the main group, pain indicators, as well as bleeding and swelling, according to a patient survey, were less pronounced. The early wound healing index was also more positive in the main group - on days 3, 7 and 14 there was a more intense decrease. (1.9 points.,1.5 points., 1.2 points., respectively, and in the control group 2.3 points., 2.1 points., 1.9 points.). Conclusion: Local application of alginate plates with a complex of antimicrobial peptides and cytokines in the early postoperative period allows to improve early wound healing after surgical interventions on periodontal tissues, and can be recommended for use at a dental appointment, as well as for use at home.
Databáze:	MEDLINE
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