Full-Field Electroretinogram Responses in Rodent Models of Ganglion Cell Injury.

Autor:	Zhao D; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Lee PY; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Wong VHY; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Hoang A; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Tran KKN; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Van Koeverden AK; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Afiat BC; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Nguyen CTO; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia., Bui BV; Department of Optometry and Vision Sciences, University of Melbourne, Parkville, VIC, Australia. bvb@unimelb.edu.au.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2858, pp. 207-218.
DOI:	10.1007/978-1-0716-4140-8_17
Abstrakt:	Preclinical studies of optic nerve injury models have led to significant insight into the mechanism underlying retinal ganglion cell neurodegeneration. During the process of ganglion cell injury, morphological changes can occur prior to gross structural changes and cell death. Similarly, following injury, functional changes can occur in the absence of substantive structural changes. These more subtle effects can often be detected using functional tools such as the electroretinogram. Moreover, the electroretinogram is a sensitive and complementary means to quantify treatment efficacy. Here, we describe in vivo electroretinography for assessing ganglion cell injury in rodent models. (© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze:	MEDLINE
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