Perioperative management of antithrombotic therapy in elderly patients undergoing lumbar discectomy: a retrospective study on 163 patients.

Autor: Corazzelli G; Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy. GiuCoraz@gmail.com., Corvino S; Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, 'Federico II' University, Naples, Italy., Ricciardi F; Department of Neurosurgery, IRCCS Neuromed, Pozzilli (IS), Italy., Pizzuti V; Department of Neurosurgery, IRCCS Neuromed, Pozzilli (IS), Italy., Leonetti S; Department of Neurosurgery, IRCCS Neuromed, Pozzilli (IS), Italy., D'Elia A; Department of Neurosurgery, IRCCS Neuromed, Pozzilli (IS), Italy., Santilli M; Department of Neurology, IRCCS Neuromed, Pozzilli, Italy., Aloj F; Anaesthesiological Department, IRCCS Neuromed, Pozzilli (IS), Italy., Innocenzi G; Department of Neurosurgery, IRCCS Neuromed, Pozzilli (IS), Italy.
Jazyk: angličtina
Zdroj: Neurosurgical review [Neurosurg Rev] 2024 Oct 21; Vol. 47 (1), pp. 807. Date of Electronic Publication: 2024 Oct 21.
DOI: 10.1007/s10143-024-03059-8
Abstrakt: Background Context: The prevalence of lumbar disc herniation (LDH) has risen alongside the aging population, often necessitating neurosurgical intervention. However, managing antithrombotic medications in elderly patients with a history of major cardiovascular events (MACE) presents challenges, as treatment may require modification or cessation. This study aims to compare surgical outcomes among elderly patients receiving antithrombotic drugs and assess their impact and potential complications. The findings aim to inform the management of elderly patients with cardiovascular and spinal conditions undergoing neurosurgery.
Methods: This retrospective, observational study was conducted at a single center. A total of 163 patients aged 60 or above who underwent lumbar discectomy for LDH were included. Patients were categorized into three groups based on their antithrombotic drug management: Group A (46 patients) replaced antiplatelet agents with low-dose aspirin for secondary prevention, Group B (54 patients) discontinued antiplatelet agents for primary prevention one week preoperatively and replaced them with LMWH, and Group C (63 patients) did not receive antithrombotic medication. Intraoperative blood loss, surgical time, and postoperative hospitalization were analyzed across all three groups. Continuous variables were compared between groups using the two-tailed Mann-Whitney test, with significance set at p < 0.05.
Results: No significant differences were found in intraoperative blood loss or surgical time among groups A, B, and C. Similarly, no significant differences were observed between groups B and C across all analyzed variables. No early or delayed hemorrhagic complications occurred perioperatively or during the 3-month postoperative follow-up period.
Conclusions: The study suggests that elective discectomy surgery in patients receiving anticoagulant and antiplatelet therapies may proceed without early complications and can be safely continued perioperatively. These findings have implications for the management of elderly patients requiring neurosurgical intervention in the context of cardiovascular comorbidities.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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