Comparison of autism spectrum disorder subtypes based on functional and structural factors.

Autor:	Wang S; Department of Information and Communications Engineering, School of Engineering, Tokyo Institute of Technology, Yokohama, Japan., Sun Z; Graduate School of Medicine, Juntendo University, Tokyo, Japan.; Faculty of Health Data Science, Juntendo University, Tokyo, Japan., Martinez-Tejada LA; Department of Computer Science, School of Computing, Tokyo Institute of Technology, Yokohama, Japan., Yoshimura N; Department of Computer Science, School of Computing, Tokyo Institute of Technology, Yokohama, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Oct 04; Vol. 18, pp. 1440222. Date of Electronic Publication: 2024 Oct 04 (Print Publication: 2024).
DOI:	10.3389/fnins.2024.1440222
Abstrakt:	Autism spectrum disorder (ASD) is a series of neurodevelopmental disorders that may affect a patient's social, behavioral, and communication abilities. As a typical mental illness, ASD is not a single disorder. ASD is often divided into subtypes, such as autism, Asperger's, and pervasive developmental disorder-not otherwise specified (PDD-NOS). Studying the differences among brain networks of the subtypes has great significance for the diagnosis and treatment of ASD. To date, many studies have analyzed the brain activity of ASD as a single mental disorder, whereas few have focused on its subtypes. To address this problem, we explored whether indices derived from functional and structural magnetic resonance imaging (MRI) data exhibited significant dissimilarities between subtypes. Utilizing a brain pattern feature extraction method from fMRI based on tensor decomposition, amplitude of low-frequency fluctuation and its fractional values of fMRI, and gray matter volume derived from MRI, impairments of function in the subcortical network and default mode network of autism were found to lead to major differences from the other two subtypes. Our results provide a systematic comparison of the three common ASD subtypes, which may provide evidence for the discrimination between ASD subtypes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Wang, Sun, Martinez-Tejada and Yoshimura.)
Databáze:	MEDLINE
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