Progressive T1 high-intensity plaques in carotid stenosis: Comparative MRI analyses in asymptomatic and symptomatic phases of low-grade stenosis.

Autor: Kurosaki Y; Department of Neurosurgery, Kurashiki Central Hospital, Kurashiki, 710-8602, Japan. Electronic address: kurosaki0106@gmail.com., Kinosada M; Department of Neurosurgery, Kurashiki Central Hospital, Kurashiki, 710-8602, Japan., Ikeda H; Department of Neurosurgery, Kurashiki Central Hospital, Kurashiki, 710-8602, Japan., Yamashita H; Department of Neurosurgery, Kyoto University School of Medicine, Kyoto, 606-8501, Japan., Yoshida K; Department of Neurosurgery, Shiga University School of Medicine, 520-2192, Otsu, Japan., Chin M; Department of Neurosurgery, Kurashiki Central Hospital, Kurashiki, 710-8602, Japan.
Jazyk: angličtina
Zdroj: Journal of neuroradiology = Journal de neuroradiologie [J Neuroradiol] 2024 Nov; Vol. 51 (6), pp. 101223. Date of Electronic Publication: 2024 Oct 16.
DOI: 10.1016/j.neurad.2024.101223
Abstrakt: Background and Purpose: Carotid artery stenosis, particularly the progression from asymptomatic to symptomatic lesions, is a key factor in cerebrovascular events. This study identifies predictors of symptom development in low-grade carotid stenosis (<50%), focusing on intraplaque hemorrhage (IPH) and dynamic plaque changes.
Materials and Methods: We conducted a retrospective study analyzing 30 cases of symptomatic low-grade carotid stenosis, using carotid MRI before and after symptom onset. Key measures included relative plaque signal intensity (rSI) and high-intensity plaque (HI plaque) volume. Stepwise regression analysis examined the influence of these factors on Symptomatic rSI, Symptomatic plaque volume, and NIHSS scores.
Results: Significant increases were observed in rSI (1.32 ± 0.32 to 1.69 ± 0.25, p < 0.001) and HI plaque volume (296.4 ± 362.7 mm³ to 717.5 ± 554.9 mm³, p < 0.001) from asymptomatic to symptomatic phases. Past smoking (p = 0.008) and statin use (p = 0.04) were associated with higher Symptomatic rSI, while poor risk factor control (p = 0.03) was negatively associated. Female sex (p = 0.007) and current smoking (p = 0.009) were linked to smaller Symptomatic plaque volumes, while ischemic heart disease (p = 0.0002) and poor risk factor control (p = 0.002) predicted larger plaque volumes. Larger plaques were correlated with higher NIHSS scores (p = 0.002).
Conclusions: IPH and plaque volume are key markers of progression in low-grade carotid stenosis. Poor control of cardiovascular risk factors and a history of ischemic heart disease contribute to plaque burden and stroke severity. Continuous monitoring and strict risk management are essential in reducing stroke severity in these patients.
Competing Interests: Declaration of competing interest This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
(Copyright © 2024 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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