Alcohol and cannabis co-use: Probing subjective response in eliciting cross-substance craving.

Autor: McManus KR; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 USA., Venegas A; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 USA., Cooper ZD; UCLA Center for Cannabis and Cannabinoids, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA; Department of Anesthesiology and Perioperative Medicine, University of California, Los Angeles, CA 90095, USA., Ray LA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: lararay@psych.ucla.edu.
Jazyk: angličtina
Zdroj: Addictive behaviors [Addict Behav] 2025 Jan; Vol. 160, pp. 108189. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.addbeh.2024.108189
Abstrakt: The co-use of alcohol and cannabis is rising in prevalence, yet the mechanisms driving individuals to co-use are not well understood. Subjective response to alcohol or cannabis may predict the desire to use either substance. However, which specific facets of subjective response predict cross-substance craving remains unclear. The present study investigated whether acute administration of alcohol or cannabis facilitates cue-induced craving for the other substance, with an emphasis on the underlying subjective response mechanisms contributing to co-use. This is a secondary analysis of a behavioral pharmacology study that combined alcohol/cannabis administration with a cross-substance cue-reactivity paradigm in individuals who were heavy alcohol and heavy cannabis co-users. Over two sessions, twenty-nine individuals (17M/12F) self-administered alcohol or cannabis (in a crossover design), and then completed a cue-reactivity exercise with the other substance. Analyses tested how changes in subjective response variables following substance administration predicted cross-substance cue-induced craving. Following alcohol administration, greater subjective ratings of positive mood predicted significantly greater cue-induced cannabis craving (β = 1.14, SE = 0.41, t = 2.80, p = 0.010). Following cannabis administration, lower subjective effects ratings of positive mood/arousal predicted significantly greater cue-induced alcohol craving (β = -1.08, SE = 0.38, t = -2.85, p = 0.009; β = -2.38, SE = 1.13, t = -2.10, p = 0.047). This study identified subject response mechanisms contributing to cross-substance cue induced craving. These mechanisms include increases in positive mood following alcohol use and decreases in positive mood and arousal, akin to increases in relaxation, following cannabis use.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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