| Autor: |
Shah Hosseini R; Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey., Nouri SM; Zanjan University of medical science, Zanjan, Iran., Bansal P; Department of Biotechnology and Genetics, Jain (Deemed-to-be) University, Bengaluru, Karnataka, India.; Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, India., Hjazi A; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia., Kaur H; School of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, India.; Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, India., Hussein Kareem A; College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq., Kumar A; Department of Nuclear and Renewable Energy, Ural Federal University Named after the First President of Russia Boris Yeltsin, Ekaterinburg, Russia., Al Zuhairi RAH; National University of Science and Technology, Dhi Qar, Iraq., Al-Shaheri NA; Department of Anesthesiology, Al-Noor University College, Nineveh, Iraq., Mahdavi P; Department of Obstetrics and Gynecology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. |
| Abstrakt: |
One of the main health issues in the modern world is cancer, with breast cancer (BC) as one of the most common types of malignancies. Different environmental and genetic risk factors are involved in the development of BC. One of the primary genes implicated in cancer development is the p53 gene, which is also known as the "gatekeeper" gene. p53 is involved in cancer development by interacting with numerous pathways and signaling factors, including microRNAs (miRNAs). miRNAs are small noncoding RNA molecules that regulate gene expression by binding to the 3' untranslated region of target mRNAs, resulting in their translational inhibition or degradation. If the p53 gene is mutated or degraded, it can contribute to the risk of BC by disrupting the expression of miRNAs. Similarly, the disruption of miRNAs causes the negative regulation of p53. Therefore, the p53/miRNA axis is a crucial pathway in the progression or prevention of BC, and understanding the regulation and function of this pathway may contribute to the development of new therapeutic strategies to help treat BC. |
