Understanding the Antidepressant Mechanisms of Acupuncture: Targeting Hippocampal Neuroinflammation, Oxidative Stress, Neuroplasticity, and Apoptosis in CUMS Rats.

Autor: Li J; Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, People's Republic of China., Wu X; The Fifth Hospital of Xiamen, Xiamen, Fujian, People's Republic of China., Yan S; Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China., Shen J; Longyan Hospital of Traditional Chinese Medicine Affiliated to Xiamen University, Longyan, Fujian, People's Republic of China., Tong T; Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, People's Republic of China., Aslam MS; School of Traditional Chinese Medicine, Xiamen University Malaysia, Sepang, Malaysia., Zeng J; Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China., Chen Y; First Clinical College, Yunnan University of Chinese Medicine, Kunming, Yunnan, People's Republic of China., Chen W; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People's Republic of China., Li M; Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, People's Republic of China., You Z; Second Clinical College, Shanxi University of Traditional Chinese Medicine, Taiyuan, Shanxi, People's Republic of China., Gong K; Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China., Yang J; Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China., Zhu M; The Fifth Hospital of Xiamen, Xiamen, Fujian, People's Republic of China. 1336620278@qq.com., Meng X; Department of Traditional Chinese Medicine, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. mengxianjun@xmu.edu.cn.
Jazyk: angličtina
Zdroj: Molecular neurobiology [Mol Neurobiol] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1007/s12035-024-04550-5
Abstrakt: Depression is recognized globally as one of the most intractable diseases, and its complexity and diversity make treatment extremely challenging. Acupuncture has demonstrated beneficial effects in various psychiatric disorders. However, the underlying mechanisms of acupuncture's antidepressant action, particularly in depression, remain elusive. Therefore, this study aimed to investigate the effects of acupuncture on chronic unpredictability stress (CUMS)-induced depressive symptoms in rats and to further elucidate its underlying molecular mechanisms. All rats were exposed to CUMS of two stressors every day for 28 days, except for the control group. One hour before CUMS, rats were given a treatment with acupuncture, electroacupuncture, sham-acupuncture, or fluoxetine (2.1 mg/kg). Behavioral tests and biological detection methods were conducted in sequence to evaluate depression-like phenotype in rats. The findings of this study demonstrate that acupuncture therapy effectively ameliorated depression-like behavior induced by CUMS in rats. Additionally, acupuncture exerted a restorative effect on the alterations induced by CUMS in the levels of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), postsynaptic density95 (PSD95), gamma-aminobutyric acid (GABA), and acetylcholine (ACh). Additionally, our findings indicate that acupuncture also modulates the ERK and Caspase-3 apoptotic pathways in the hippocampus of CUMS rats. This study suggests that acupuncture may play a potential preventive role by regulating hippocampal neuroinflammatory response, levels of oxidative stress, apoptotic processes, and enhancing synaptic plasticity.
(© 2024. The Author(s).)
Databáze: MEDLINE
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