Association of Liver Disease and Chronic Pruritus: A Case-Control Study.

Autor: Andrade LF; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida, USA., Haq Z; Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA., Abdi P; Faculty of Medicine, Memorial University, St. Johns, Newfoundland, Canada., Diaz MJ; College of Medicine, University of Florida, Gainesville, Florida, USA., Levy C; Schiff Center for Liver Diseases, University of Miami Hospital, University of Miami, Miami, Florida, USA., Yosipovitch G; Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jazyk: angličtina
Zdroj: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2024 Oct 18. Date of Electronic Publication: 2024 Oct 18.
DOI: 10.1111/liv.16126
Abstrakt: Background & Methods: Through the identification of 22 803 cases of chronic pruritus, with a control group comprising 91 212 participants from a national database, we performed a comparative analysis revealing that patients with chronic pruritus had a significantly higher prevalence of liver disease compared to controls.
Results: Upon reverse analysis, we similarly found patients with liver disease had a significantly higher prevalence of chronic pruritus. Subsequent multivariate logistic regression highlighted increased odds for several liver diseases in the pruritus cohort, including metabolic dysfunction-associated steatotic liver disease (aOR 1.65, 95% CI 1.53-1.78) and alcohol-related liver disease (aOR 1.69, 95% CI 1.43-1.98). The increased odds were most pronounced for hepatitis B (aOR 2.01, 95% CI 1.67-2.42) and cholangitis + primary sclerosing cholangitis + primary biliary cholangitis (aOR 1.81, 95% CI 1.65-1.99).
Conclusion: Our results reveal a strong correlation between pruritus in hepatic pathologies different than commonly reported cholestatic diseases.
(© 2024 The Author(s). Liver International published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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