Effects of a high-protein, low-glycemic-index diet on body weight and waist circumference in late postmenopausal women: a randomized controlled trial.

Autor:	Silva TR; Universidade Federal do Rio Grande do Sul Programa de Pós-graduação em Endocrinologia e Metabolismo Porto AlegreRS Brasil Programa de Pós-graduação em Endocrinologia e Metabolismo, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.; Hospital de Clínicas de Porto Alegre Serviço de Endocrinologia Unidade de Endocrinologia Ginecológica Porto AlegreRS Brasil Unidade de Endocrinologia Ginecológica, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brasil.; Universidade Federal do Rio Grande do Sul Laboratório de Endocrinologia Molecular Departamento de Fisiologia Porto AlegreRS Brasil Departamento de Fisiologia, Laboratório de Endocrinologia Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil., Lago SC; Hospital de Clínicas de Porto Alegre Serviço de Endocrinologia Unidade de Endocrinologia Ginecológica Porto AlegreRS Brasil Unidade de Endocrinologia Ginecológica, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brasil., Fighera TM; Universidade Federal do Rio Grande do Sul Programa de Pós-graduação em Endocrinologia e Metabolismo Porto AlegreRS Brasil Programa de Pós-graduação em Endocrinologia e Metabolismo, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.; Hospital de Clínicas de Porto Alegre Serviço de Endocrinologia Unidade de Endocrinologia Ginecológica Porto AlegreRS Brasil Unidade de Endocrinologia Ginecológica, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brasil., Spritzer PM; Universidade Federal do Rio Grande do Sul Programa de Pós-graduação em Endocrinologia e Metabolismo Porto AlegreRS Brasil Programa de Pós-graduação em Endocrinologia e Metabolismo, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.; Hospital de Clínicas de Porto Alegre Serviço de Endocrinologia Unidade de Endocrinologia Ginecológica Porto AlegreRS Brasil Unidade de Endocrinologia Ginecológica, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brasil.; Universidade Federal do Rio Grande do Sul Laboratório de Endocrinologia Molecular Departamento de Fisiologia Porto AlegreRS Brasil Departamento de Fisiologia, Laboratório de Endocrinologia Molecular, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2024 Aug 26; Vol. 68, pp. e230370. Date of Electronic Publication: 2024 Aug 26 (Print Publication: 2024).
DOI:	10.20945/2359-4292-2023-0370
Abstrakt:	Objective: To describe the secondary outcomes (weight loss, waist circumference [WC], and glycolipid profile) of a previous randomized controlled trial designed to investigate the impact of a high-protein, low-glycemic-index (GI) diet on lean body mass in late postmenopausal women. Subjects and Methods: A total of 26 healthy women aged ≥ 65 years and with a mean body mass index (BMI) of 26.1 ± 3.5 kg/m 2 were randomly assigned to follow a low-GI diet (GI < 55) with protein consumption at the current recommended dietary allowance (RDA, 0.8 g/kg body weight) or twice the RDA (2RDA, 1.6 g/kg body weight). Changes in body weight, BMI, WC, glucose, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, and triglycerides were assessed at 3- and 6-month of follow-up in all participants. An intention-to-treat analysis was performed using a linear mixed model. Results: Weight loss (mean change -1.7 kg, 95% confidence interval [CI] -2.8 to -0.5 kg, p = 0.004) was observed at 6 months, with no significant difference between the RDA and 2RDA groups. An overall significant WC decrease was observed at 6 months in all participants (mean change -3.8 cm, 95% CI -5.5 to -2.1 cm, p < 0.001), with no differences between groups. The glycolipid profile remained unchanged after 6 months of dietary intervention. Conclusion: Increasing protein intake did not lead to greater weight loss or reduction in WC in a sample of healthy postmenopausal women following a low-GI diet for 6 months. Competing Interests: Disclosure: the authors declare no conflicts of interest. The funding sponsors had no role in the design of the study, in the collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.
Databáze:	MEDLINE
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