Exosomal therapy mitigates silver nanoparticles-induced neurotoxicity in rats.

Autor:	Elden Hassan HSS; Department of Biotechnology and Life Sciences, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni Suef, Egypt., Moselhy WA; Toxicology and Forensic Medicine- Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt., Ibrahim MA; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Zaki AH; Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni Suef, Egypt., Khalil F; Animal and Poultry Management and Wealth Development Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, Egypt., Hassanen EI; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Abdel-Gawad DRI; Lecturer of Toxicology and Forensic Medicine- Faculty of Veterinary Medicine, Beni-Suef University, Beni Suef, Egypt.
Jazyk:	angličtina
Zdroj:	Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2024 Nov; Vol. 29 (7), pp. 442-458. Date of Electronic Publication: 2024 Oct 17.
DOI:	10.1080/1354750X.2024.2415072
Abstrakt:	Introduction: Our investigation aims to appraise the neuroprotective impact of Bone Marrow-Mesenchymal Stem Cells (BM-MSCs) derived exosomes against Ag NPs-inducing neurotoxicity in rats. Materials and Methods: Twenty-four albino rats were divided into 3 groups. Group I (control negative), Group II (intraperitoneally injected with Ag NPs for 28 days, whereas Group III (intraperitoneally injected with Ag NP and BM-MSCs derived exosomes. Results: There was a marked elevation of Malondialdehyde (MDA) along with a reduction of brain antioxidants, Gamma-aminobutyric acid (GABA) and Monoamine Oxidase (MAO) in the Ag NPs receiving group. Ag NPs upregulated c-Jun N-terminal Kinases (JNK) genes and c-Myc and downregulated the tissue inhibitors of metalloproteinases (TIMP-1) and Histone deacetylase 1 (HDAC1) genes. Otherwise, the co-treatment of BM-MSCs derived exosomes with Ag NPs could markedly increase the rat's body weight, activity and learning while, decreasing anxiety, restoring all the toxicological parameters and improving the microscopic appearance of different brain areas. Conclusion: BM-MSCs-derived exosomes downregulated both apoptotic and inflammatory mediators and upregulated the antiapoptotic genes. BM-MSCs-derived exosomes exhibit a great therapeutic effect against the neurotoxic effects of Ag NPs.
Databáze:	MEDLINE
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