Idiopathic multicentric Castleman disease.

Autor:	Chaudhari V; Department of Gastroenterology, Lokamanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Thakkar SJ; Department of Medicine, Lokamanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Padwal N; Department of Medicine, Lokamanya Tilak Municipal Medical College, Mumbai, Maharashtra, India., Karnik N; Department of Medicine, Lokamanya Tilak Municipal Medical College, Mumbai, Maharashtra, India.
Jazyk:	angličtina
Zdroj:	Journal of cancer research and therapeutics [J Cancer Res Ther] 2024 Jul 01; Vol. 20 (5), pp. 1602-1604. Date of Electronic Publication: 2023 Apr 04.
DOI:	10.4103/jcrt.jcrt_2190_22
Abstrakt:	Abstract: An elderly man presented with fever and chills for six months, associated with loss of appetite and weight loss, bilateral edema, and non-tender inguinal lymphadenopathy. The left-sided testicle was bulky, firm, and non-tender. Investigations revealed anemia, leukopenia, elevated erythrocyte sedimentation rate, and hypergammaglobulinemia. Ultrasound of the abdomen revealed multiple enlarged necrotic lymph nodes in the periaortic, preaortic, precaval, and bilateral pelvic regions. Fine-needle aspiration cytology (FNAC) of the inguinal nodes showed no acid-fast bacilli (AFB). However, excision biopsy revealed lymphoid tissue with effacement of architecture by diffuse proliferation of mature plasma cells, suggestive of the plasma cell variant of multicentric Castleman disease. Due to suspicion of neoplastic testicular enlargement, the patient underwent bilateral orchidectomy, and histopathology showed hematocele with atrophy of the testis and secondary involvement of the testicular parenchyma by plasma cell variant of Castleman disease. (Copyright © 2023 Copyright: © 2023 Journal of Cancer Research and Therapeutics.)
Databáze:	MEDLINE
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