Variables Associated With In-Hospital Lethality in COVID-19: A Prospective Cohort Study From Colombia.

Autor:	Lora Mantilla AJ; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Cáceres Ramírez C; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Riaño Duarte AK; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Amaya Muñoz MC; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Ayala-Gutierrez MC; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Villabona SJ; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Cala Duran JC; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Camacho López PA; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL., Gomez Laitton ED; Research, Development, and Technological Innovation Department, Fundación Oftalmológica de Santander, Floridablanca, COL.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Sep 13; Vol. 16 (9), pp. e69368. Date of Electronic Publication: 2024 Sep 13 (Print Publication: 2024).
DOI:	10.7759/cureus.69368
Abstrakt:	Introduction: The emergence of COVID-19 represents the most significant health crisis in recent history. Incidence and mortality rates depend on several factors. Many studies have focused on investigating which characteristics could be strongly related to higher mortality and lethality. Objective: This study aims to analyze the variables associated with in-hospital mortality among patients admitted in a reference northeastern region of a Colombian institution. Methods: An ambidirectional cohort, single-center study was carried out in a reference hospital in northeastern Colombia. All patients admitted to the Fundación Oftalmológica de Santander (FOSCAL) between March 2020 and September 2021, with COVID-19 real-time polymerase chain reaction (PCR) positive test, were included. Results: A total of 3,028 patients were included, of whom 2,034 (67.8%) survived and 994 (32.8%) died during their hospital stay; 48.8% (1,479) of the patients were female. The most common comorbidities were hypertension (1,236 patients, 40.8%), obesity (body mass index (BMI) ≥ 30; 656 patients, 21.6%), and diabetes (618 patients, 20.4%). The average age of the surviving patients was 52.2 years, while for the deceased patients, it was 70.3 years. The variables that showed significant association with in-hospital mortality were as follows: male sex ≥ 45 years, dyspnea, oxygen saturation (SatO2) < 85%, hypertension, chronic kidney disease (CKD), and a Charlson Comorbidity Index (CCI) score of >1. Conclusions: Male sex, age ≥ 45 years, dyspnea, SatO2 < 85%, hypertension, CKD, and a CCI score of >1 were associated with a higher risk of in-hospital mortality in COVID-19-infected patients. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Research Ethics Committee CEI-Fundación Oftalmológica de Santander (FOSCAL) issued approval 02895/2020. It is approved expediently and the approval is ratified. The Research and Ethics Committee of the Fundación Oftalmológica de Santander (FOSCAL) deems that the project meets all the required quality standards. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Lora Mantilla et al.)
Databáze:	MEDLINE
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