The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation.

Autor: Bahr TM; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. tim.bahr@imail.org.; Department of Neonatology, Intermountain Health, Murray, UT, USA. tim.bahr@imail.org., Ohls RK; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Henry E; Department of Neonatology, Intermountain Health, Murray, UT, USA., Davenport P; Division of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Ilstrup SJ; Transfusion Services and Department of Pathology, Intermountain Health, Murray, UT, USA., Kelley WE; American National Red Cross, Salt Lake City, UT, USA.; Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA., Yoder BA; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Sola-Visner MC; Division of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Christensen RD; Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.; Department of Neonatology, Intermountain Health, Murray, UT, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Oct 15. Date of Electronic Publication: 2024 Oct 15.
DOI: 10.1038/s41372-024-02135-7
Abstrakt: Objective: We previously reported the possible pathogenic role, among infants born ≤29 weeks, of transfusions in bronchopulmonary dysplasia. The present study examined this association in infants born >31 weeks.
Study Design: Analysis of red blood cell (RBC) and platelet transfusions in five NICUs to infants born >31 weeks, and chronic neonatal lung disease (CNLD) at six-weeks of age.
Results: Seven-hundred-fifty-one infants born >31 weeks were still in the NICU when six-weeks of age. CNLD was identified in 397 (53%). RBC and platelet transfusions were independently associated with CNLD after controlling for potential confounders. For every transfusion, the adjusted odds of developing CNLD increased by a factor of 1.64 (95% CI, 1.38-2.02; p < 0.001).
Conclusions: Among NICU patients born >31 weeks, transfusions received by six weeks are associated with CNLD incidence and severity. Though we controlled for known confounding variables in our regression models, severity of illness is an important confounder that limits our conclusions.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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