Brain tissue oxygen pressure combined with intracranial pressure monitoring may improve clinical outcomes for patients with severe traumatic brain injury: a systemic review and meta-analysis.
| Autor: | Zhang C; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Emergency Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, China., Zhou L; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Critical Care Medicine, First People's Hospital of Taizhou, Taizhou, China., Zhang K; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Huang J; Department of Critical Care Medicine, Hangzhou Ninth People's Hospital, Hangzhou, China., Cao L; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Lou Y; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Fan Y; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhang X; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wang Y; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Cui W; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Hu L; Department of Critical Care Medicine, Hospital of Zhejiang People's Armed Police, Hangzhou, China., Zhang G; Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Key Laboratory of Multiple Organ Failure (Zhejiang University), Ministry of Education, Hangzhou, China. |
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| Jazyk: | angličtina |
| Zdroj: | PeerJ [PeerJ] 2024 Oct 08; Vol. 12, pp. e18086. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024). |
| DOI: | 10.7717/peerj.18086 |
| Abstrakt: | Background: Although the optimization of brain oxygenation is thought to improve the prognosis, the effect of brain tissue oxygen pressure (PbtO2) for patients with severe traumatic brain injury (STBI) remains controversial. Therefore, the present study aimed to determine whether adding PbtO2 to intracranial pressure (ICP) monitoring improves clinical outcomes for patients with STBI. Methods: PubMed, Embase, Scopus and Cochrane Library were searched for eligible trials from their respective inception through April 10th, 2024. We included clinical trials contrasting the combined monitoring of PbtO Results: A total of 16 studies (four randomized studies and 12 cohort studies) were included in the meta-analysis. Compared with isolated ICP monitoring, the combined monitoring was associated with a higher favorable neurological outcome rate at 6 months (RR 1.33, 95% CI [1.17-1.51], P < 0.0001, I 2 = 0%), reduced long-term mortality (RR 0.72, 95% CI [0.59-0.87], P = 0.0008, I 2 = 2%). No significant difference was identified in the in-hospital mortality (RR 0.81, 95% CI 0.66 to 1.01, P = 0.06, I 2 = 32%), length of stay in ICU (MD 2.10, 95% CI [-0.37-4.56], P = 0.10, I 2 = 78%) and hospital (MD 1.07, 95% CI [-2.54-4.67], P = 0.56, I 2 = 49%) between two groups. However, the pooled results of randomized studies did not show beneficial effect of combined monitoring in favorable neurological outcome and long-term mortality. Conclusions: Currently, there is limited evidence to prove that the combined PbtO2 and ICP monitoring may contribute to improved neurological outcome and long-term mortality for patients with STBI. However, the benefit of combined monitoring should be further validated in more randomized studies. Competing Interests: The authors declare there are no competing interests. (©2024 Zhang et al.) |
| Databáze: | MEDLINE |
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