Initial Patient Characteristics of TSOG 102: A Multicenter Prospective Registry of Active Surveillance in Patients with Multiple Ground Glass Opacities.

Autor:	Huang J; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: huangj@mskcc.org., Tan KS; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY., Altorki N; Department of Cardiothoracic Surgery, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY., Antonoff M; Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX., Blackmon S; Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN., Bueno R; Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA., Burt B; Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX., Demmy T; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Evans N; Division of Thoracic Surgery, Department of Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA., Donahoe L; Division of Thoracic Surgery, University Health Networks/Toronto General Hospital, Toronto, Ontario, Canada., Harpole D; Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC., Jarrar D; Division of Thoracic Surgery, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Pennsylvania, PA., Kozower B; Department of Surgery, Washington University School of Medicine in Saint Louis, St. Louis, MO., Lanuti M; Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA., Liberman M; Division of Thoracic Surgery, University of Montreal, Montreal, Quebec, Canada., Lin J; Michigan Medicine, Section of Thoracic Surgery, Department of Surgery, Ann Arbor, MI., Liou D; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, CA., Liptay M; Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL., Luketich J; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA., Pennathur A; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA., Petersen G; Lehigh Valley Health Network, Allentown, PA., Ripley R; Department of Thoracic Surgery, Baylor College of Medicine, Houston, TX., Rochefort M; Department of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA., Seder CW; Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL., Shrager J; Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, CA., Su S; Division of Thoracic Surgery, Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA., Tong B; Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC., Shargall Y; Division of Thoracic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada., Vaporciyan A; Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, TX., Waddell T; Division of Thoracic Surgery, University Health Networks/Toronto General Hospital, Toronto, Ontario, Canada., Weksler B; Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, PA., Wigle D; Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN., Yendamuri S; Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Jones DR; Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Jazyk:	angličtina
Zdroj:	The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.
DOI:	10.1016/j.jtcvs.2024.09.054
Abstrakt:	Objective: Presentation with multiple ground glass opacities (GGOs) is an increasingly common occurrence, and the optimal management of these lesions is unclear. Active surveillance has been increasingly adopted as a management strategy for other low-grade malignancies. We hypothesized that active surveillance could be a feasible and safe option for patients with multiple GGOs. Methods: Patients with ≥2 GGOs (ground glass predominant, <50% solid, ≤3 cm) were enrolled in a multi-institutional registry and prospectively followed up on active surveillance with computed tomography scans every 6 to 12 months. Each GGO was catalogued and measured individually at each follow-up visit. Results: Target accrual was met, with 337 patients from 23 institutions. The mean age was 70 years (interquartile range, 65-77 years), and 74% were women. Most were former (70%) or current (9%) smokers, with a mean exposure of 30 pack-years (interquartile range [IQR], 15-44 pack-years). Half of the patients (51%) had a previous lung cancer, and the majority (86%) were already under surveillance at the time of study entry. The median number of GGOs per patient was 3 (IQR, 2-5), with a total of 1467 GGOs under surveillance. The median GGO size was 0.9 cm (IQR, 0.7-1.3 cm). Most GGOs were 0.5 to 1 cm in size. Conclusions: Active surveillance, rather than immediate intervention, was an acceptable option to patients, and accrual to this registry trial was feasible. Safety endpoints and long-term outcomes will be assessed in the planned 5-year follow-up in accordance with the protocol. (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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