Efinaconazole 10% solution: a comprehensive review of its use in the treatment of onychomycosis.
| Autor: | Gupta AK; Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Mediprobe Research Inc, London, ON, Canada., Mann A; Mediprobe Research Inc, London, ON, Canada., Polla Ravi S; Mediprobe Research Inc, London, ON, Canada., Wang T; Mediprobe Research Inc, London, ON, Canada., Cooper EA; Mediprobe Research Inc, London, ON, Canada. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2024 Oct; Vol. 25 (15), pp. 1983-1998. Date of Electronic Publication: 2024 Oct 16. |
| DOI: | 10.1080/14656566.2024.2416924 |
| Abstrakt: | Introduction: Onychomycosis is an infection of the nail bed and the nail plate. While oral antifungals are first-line for moderate-to-severe onychomycosis, topical efinaconazole 10% solution (JUBLIA®; Clenafin®) is effective and safe for mild-to-moderate severity onychomycosis. It is FDA-approved for patients aged 6 years and above. Areas Covered: This literature review includes pharmacokinetics, microbiology, efficacy, safety, and post-marketing surveillance. It demonstrates consistent safety and efficacy across diverse patient demographics and comorbidities, including pediatric, diabetic and the elderly populations, without systemic side effects or drug interactions. Expert Opinion: Efinaconazole 10% solution is an important addition to the armamentarium of therapies available to treat onychomycosis. Certain subgroups respond particularly well: females versus males, children versus adults, early onset onychomycosis (<1-year disease), those with mild onychomycosis (≤25% nail involvement), absence of tinea pedis, and thin nail plates at baseline (<1 mm thickness). Efinaconazole 10% solution is effective in diabetics and has demonstrated efficacy against dermatophytomas. Efinaconazole may be a consideration when terbinafine resistance is a concern, due to its different target of action. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|