Radiation Therapy Dose for Limited-stage Extranodal Marginal Zone Lymphomas of the Mucosa-associated Lymphoid Tissues of the Stomach: A Meta-analysis.

Autor:	Cho SH; Department of Radiation Oncology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea., Yang KS; Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea., Kang KW; Division of Hematology and Oncology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: ggm1018@gmail.com., Lee NK; Department of Radiation Oncology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: nklee74@korea.ac.kr.
Jazyk:	angličtina
Zdroj:	Practical radiation oncology [Pract Radiat Oncol] 2024 Oct 10. Date of Electronic Publication: 2024 Oct 10.
DOI:	10.1016/j.prro.2024.09.008
Abstrakt:	Purpose: To compare the outcomes of 2 standard radiation therapy (RT) doses for limited-stage gastric extranodal marginal zone lymphoma (EMZL) of the mucosa-associated lymphoid tissues. Methods and Materials: A database search was performed to identify articles published from database inception to August 31, 2023. Based on the current standard dose of 24.0 to 30.0 Gy, doses of approximately 30.0 Gy were classified as standard dose (SD), while those of approximately 24.0 Gy were classified as low dose (LD). Pooled estimates of the complete remission (CR) and local recurrence (LR) rates were calculated and compared. Results: Data from 1072 patients across 30 included studies were analyzed. SD was used in 28 studies (n = 987), while LD was used in 6 studies (n = 85), and both regimens were used in 4 studies. In all included studies, the CR rate was 0.96 (95% CI, 0.94-0.97), and the LR rate was 0.05 (95% CI, 0.04-0.06), showing no significant between-study heterogeneity (τ 2 = 0 and I 2 = 0% for both; P = .8447 and .9998, respectively). SD and LD resulted in no significant differences in the CR rates (0.96 [95% CI, 0.94-0.97] vs 0.96 [95% CI, 0.89-0.99]; P = .9174) or LR rates (0.05 [95% CI, 0.04-0.06] vs 0.03 [95% CI, 0.01-0.10]; P = .5495). Conclusions: Both the SD and LD groups achieved excellent CR and LR rates. These results indicate that the RT dose for limited-stage gastric EMZL may be safely de-escalated without compromising local tumor control. Competing Interests: Disclosures None. (Copyright © 2024 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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