Copper biomarkers and their relationship with parameters of insulin resistance in obese women.

Autor: da Silva NC; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., da Silva LD; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., Chaves BMS; Graduate of Nutrition, Federal University of Piauí, Teresina, Brazil., de Oliveira EHS; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., Barros EML; Postgraduate Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., de Oliveira FE; Pharmacist-Biochemist, Federal University of Piauí, Teresina, Brazil., Henriques GS; Department of Nursing, Federal University of Minas Gerais, Belo Horizonte, Brazil., Pereira IC; Postgraduate Program in Food and Nutrition, Department of Biophysics and Physiology, Teresina, Brazil., Severo JS; Postgraduate Program in Food and Nutrition, Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., Dos Santos LR; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., de Moura MSB; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., da Cunha Soares T; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., de Sousa TGV; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., de Sousa Melo SR; Postgraduate Program in Food and Nutrition, Federal University of Piauí, Teresina, Brazil., do Nascimento Marreiro D; Department of Nutrition, Health Sciences Center, Federal University of Piauí, Teresina, Brazil. dilina.marreiro@ufpi.edu.br.
Jazyk: angličtina
Zdroj: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2024 Oct 11. Date of Electronic Publication: 2024 Oct 11.
DOI: 10.1007/s10534-024-00645-7
Abstrakt: Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case-control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). The results of this study demonstrate that obese women have high copper concentrations in plasma and lower concentrations in erythrocytes. Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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