Seizure and Takotsubo Cardiomyopathy Due to Proton Pump Inhibitor.
| Autor: | Acharya I; Medstar Health Internal Medicine Residency Program, Baltimore, MD, USA., Pokharel A; Medstar Health Internal Medicine Residency Program, Baltimore, MD, USA., Grove DA; MedStar Health, MedStar Union Memorial Hospital, Baltimore, MD, USA., Haas CJ; Medstar Health Internal Medicine Residency Program, Baltimore, MD, USA.; Georgetown University School of Medicine, Washington, DC, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of community hospital internal medicine perspectives [J Community Hosp Intern Med Perspect] 2024 Jul 02; Vol. 14 (4), pp. 114-117. Date of Electronic Publication: 2024 Jul 02 (Print Publication: 2024). |
| DOI: | 10.55729/2000-9666.1360 |
| Abstrakt: | Proton Pump Inhibitor (PPI)-induced hypomagnesemia, first described in 2006, has gained increasing recognition in recent years as a potentially life-threatening adverse event. In comparison to histamine-2 receptor antagonists (H2RA), PPIs exhibit a higher frequency of electrolyte abnormalities, including hypomagnesemia, hypocalcemia, hypokalemia, and hyponatremia; hypomagnesemia is the most common. We report a case of an 80-year-old woman who presented with generalized weakness and diarrhea. She was found to have multiple electrolyte abnormalities that failed to resolve even after the resolution of diarrhea and resumption of feeding. However, her condition improved within one week of discontinuing PPI medication. Her hospital course was complicated by a seizure, attributed to alterations in ionic gradients across cellular membranes affecting neuronal discharge and facilitating epileptiform activities. Additionally, she experienced Takotsubo cardiomyopathy due to decreased myocardial contractility, both in the context of electrolyte imbalance induced by prolonged PPI use. Competing Interests: Conflicts of interest: None. (© 2024 Greater Baltimore Medical Center.) |
| Databáze: | MEDLINE |
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