The cryptic immunopeptidome in health and disease.

Autor: Kina E; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada., Larouche JD; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada., Thibault P; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada., Perreault C; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada. Electronic address: claude.perreault@umontreal.ca.
Jazyk: angličtina
Zdroj: Trends in genetics : TIG [Trends Genet] 2024 Oct 09. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.tig.2024.09.003
Abstrakt: Peptides presented by MHC proteins regulate all aspects of T cell biology. These MHC-associated peptides (MAPs) form what is known as the immunopeptidome and their comprehensive analysis has catalyzed the burgeoning field of immunopeptidomics. Advances in mass spectrometry (MS) and next-generation sequencing have facilitated significant breakthroughs in this area, some of which are highlighted in this article on the cryptic immunopeptidome. Here, 'cryptic' refers to peptides and proteins encoded by noncanonical open reading frames (ORFs). Cryptic MAPs derive mainly from short unstable proteins found in normal, infected, and neoplastic cells. Cryptic MAPs show minimal overlap with cryptic proteins found in whole-cell extracts. In many cancer types, most cancer-specific MAPs are cryptic.
Competing Interests: Declaration of interests E.K., P.T., and C.P. are named inventors on patent applications filed by Université de Montréal and covering tumor antigens. P.T. and C.P. receive grant support and consultant fees from Epitopea Inc.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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