Interplay of calcium, vitamin D, and parathormone in the milieu of infections and immunity: Reassessed in the context of COVID-19.

Autor: Bandyopadhyay U; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India., Sen D; Post Graduate Department of Physiology, Hooghly Mohsin College, University of Burdwan, West Bengal, India., Ahuja D; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India., Mahapatra SP; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India., Biswas D; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India., Maiti R; Department of Physiology, Bankura Christian College, Bankura, West Bengal, India., Chakraborty S; Abhinav Bindra Targeting Performance (ABTP), Sports Science Centre, Kalinga Stadium, Bhubaneswar, Odisha, India., Hazra A; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India., Parua S; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India., Basak AK; School of Allied Health Sciences, Brainware University, Barasat, West-Bengal, India. Electronic address: asim_bsk@rediffmail.com., Das A; Department of Sports Science & Yoga, Ramakrishna Mission Vivekananda Educational & Research Institute, Belur Math, Howrah, India., Paul N; Department of General Human Physiology and Biochemistry, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India., Purkait MP; Department of Zoology, Sonarpur Mahavidyalaya, Kolkata, West-Bengal, India., Syamal AK; Post Graduate Department of Physiology, Hooghly Mohsin College, University of Burdwan, West Bengal, India., Dey R; Department of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Barrackpore, West Bengal, India. Electronic address: rdrajen422@gmail.com., Bhattacharya K; School of Paramedics and Allied Health Sciences, Centurion University of Technology and Management, Khurda Road, Jatani, Odisha, India. Electronic address: koushik22.2009@rediffmail.com., Adhikary K; Department of Interdisciplinary Science, Centurion University of Technology and Management, Khurda Road, Bhubaneswar, Odisha, India., Bhattacharjee A; Department of Physiology, International Medical School, Management and Science University, Selangor, Malaysia.
Jazyk: angličtina
Zdroj: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2025 Jan; Vol. 245, pp. 106624. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1016/j.jsbmb.2024.106624
Abstrakt: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is recognized for inducing severe respiratory symptoms like cough, and shortness of breathing. Although symptom severity varies, some individuals remain asymptomatic. This virus has sparked a global pandemic, imposing a substantial rate of mortality or morbidity, with extended periods of illness reported. People with underlying medical issues and the elderly are more likely to experience adverse results. The virus's frequent mutations pose challenges for medical professionals, necessitating adaptable therapeutic and preventive strategies. Vitamin D, a versatile regulatory molecule, not only influences physiological processes such as serum calcium regulation but also exhibits immunomodulatory functions. Calcium ions play a crucial role as secondary signal transduction molecules, impacting diverse cellular functions and maintaining homeostasis through ion channel regulation. Parathormone, another key regulator of serum calcium, often acts antagonistically to vitamin D. This review delves into the interplay of vitamin D, calcium, and parathormone, exploring their possible influence on the progression of COVID-19. The intricate signaling involving these elements contributes to adverse prognosis, emphasizing the need for comprehensive understanding. Monitoring and controlling these physiological factors and associated pathways have shown the potential to alter disease outcomes, underscoring the importance of a holistic approach.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interests
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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