SARS-CoV2 mRNA vaccine intravenous administration induces myocarditis in chronic inflammation.

Autor: Jeon HE; Department of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk, Republic of Korea., Lee S; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea., Lee J; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea., Roh G; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea., Park HJ; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea., Lee YS; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea., Kim YJ; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea., Kim HK; Department of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk, Republic of Korea., Shin JH; Department of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk, Republic of Korea., Lee YJ; Division of Cardiology, Samsung Medical Center, 50 Irwon Dong, Gangnam-gu, Seoul, Republic of Korea., Gil CO; Division of Cardiology, Samsung Medical Center, 50 Irwon Dong, Gangnam-gu, Seoul, Republic of Korea., Jeon ES; Division of Cardiology, Samsung Medical Center, 50 Irwon Dong, Gangnam-gu, Seoul, Republic of Korea., Nam JH; Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; Department of Biotechnology, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.; SML Biopharm, Gyeonggi-do, Gwangmyeong, Republic of Korea., Lim BK; Department of Biomedical Science, Jungwon University, Goesan-gun, Chungbuk, Republic of Korea.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Oct 10; Vol. 19 (10), pp. e0311726. Date of Electronic Publication: 2024 Oct 10 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0311726
Abstrakt: The current COVID-19 mRNA vaccines were developed and applied for pandemic-emergent conditions. These vaccines use a small piece of the virus's genetic material (mRNA) to stimulate an immune response against COVID-19. However, their potential effects on individuals with chronic inflammatory conditions and vaccination routes remain questionable. Therefore, we investigated the effects of mRNA vaccines in a mouse model of chronic inflammation, focusing on their cardiac toxicity and immunogenicity dependent on the injection route. mRNA vaccine intravenous administration with or without chronic inflammation exacerbated cardiac pericarditis and myocarditis; immunization induced mild inflammation and inflammatory cytokine IL-1beta and IL-6 production in the heart. Further, IV mRNA vaccination induced cardiac damage in LPS chronic inflammation, particularly serum troponin I (TnI), which dramatically increased. IV vaccine administration may induce more cardiotoxicity in chronic inflammation. These findings highlight the need for further research to understand the underlying mechanisms of mRNA vaccines with chronic inflammatory conditions dependent on injection routes.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Jeon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje