Resilience to Chronic Stress Is Characterized by Circadian Brain-Liver Coordination.

Autor:	Savva C; Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden., Vlassakev I; Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden., Bunney BG; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, California., Bunney WE; Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, Irvine, California., Massier L; Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Seldin M; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California., Sassone-Corsi P; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California., Petrus P; Department of Medicine (H7), Karolinska Institutet, Stockholm, Sweden.; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California., Sato S; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, California.; Center for Biological Clocks Research, Department of Biology, Texas A&M University, College Station, Texas.
Jazyk:	angličtina
Zdroj:	Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2024 Aug 23; Vol. 4 (6), pp. 100385. Date of Electronic Publication: 2024 Aug 23 (Print Publication: 2024).
DOI:	10.1016/j.bpsgos.2024.100385
Abstrakt:	Background: Chronic stress has a profound impact on circadian regulation of physiology. In turn, disruption of circadian rhythms increases the risk of developing both psychiatric and metabolic disorders. To explore the role of chronic stress in modulating the links between neural and metabolic rhythms, we characterized the circadian transcriptional regulation across different brain regions and the liver as well as serum metabolomics in mice exposed to chronic social defeat stress, a validated model for studying depressive-like behaviors. Methods: Male C57BL/6J mice underwent chronic social defeat stress, and subsequent social interaction screening identified distinct behavioral phenotypes associated with stress resilience and susceptibility. Stressed mice and their control littermates were sacrificed every 4 hours over the circadian cycle for comprehensive analyses of the circadian transcriptome in the hypothalamus, hippocampus, prefrontal cortex, and liver together with assessments of the circadian circulatory metabolome. Results: Our data demonstrate that stress adaptation was characterized by reprogramming of the brain as well as the hepatic circadian transcriptome. Stress resiliency was associated with an increase in cyclic transcription in the hypothalamus, hippocampus, and liver. Furthermore, cross-tissue analyses revealed that resilient mice had enhanced transcriptional coordination of circadian pathways between the brain and liver. Conversely, susceptibility to social stress resulted in a loss of cross-tissue coordination. Circadian serum metabolomic profiles corroborated the transcriptome data, highlighting that stress-resilient mice gained circadian rhythmicity of circulating metabolites, including bile acids and sphingomyelins. Conclusions: This study reveals that resilience to stress is characterized by enhanced metabolic rhythms and circadian brain-liver transcriptional coordination. (© 2024 The Authors.)
Databáze:	MEDLINE
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