Neurodevelopmental outcomes among children with congenital gastrointestinal anomalies using Korean National Health Insurance claims data.

Autor: Cho H; Department of Pediatrics, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea., Song IG; Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea. igsong@yuhs.ac., Lim Y; Institute for Future Strategy, Seoul National University, Seoul, South Korea., Cho YM; Health Insurance Research Institute, National Health Insurance Service, Wonju, South Korea., Kim HS; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 08; Vol. 14 (1), pp. 23442. Date of Electronic Publication: 2024 Oct 08.
DOI: 10.1038/s41598-024-74515-0
Abstrakt: This study investigated neurodevelopment and risk factors in children surgically treated for congenital gastrointestinal anomalies (CGIA), excluding those with known high-risk factors such as low birth weight or chromosomal anomalies. Data of children born between 2008 and 2015 who underwent surgical treatment for CGIA were retrieved from the Korean National Health Insurance Database. CGIA included esophageal atresia, duodenal atresia, jejunoileal atresia, anorectal malformations, and congenital megacolon. Neurodevelopmental impairment (NDI) was defined as Korean Ages and Stages Questionnaire scores below the determined cut-off or Korean Developmental Screening Test scores < 2 standard deviations at 3 years of age. Children with CGIA had a significantly higher risk of NDI than controls (6.2% vs. 2.7%, p < 0.001). Growth failure was correlated with NDI. Longer durations of oxygen support (adjusted odds ratio [aOR], 1.037; 95% confidence interval [CI], 1.013-1.063), mechanical ventilation (aOR, 1.053; 95% CI, 1.018-1.089), and number of surgeries (aOR, 1.137; 95% CI, 1.016-1.273) were significantly associated with NDI. These findings emphasize that cautious yet proactive neurodevelopmental monitoring is crucial in affected children, ensuring timely intervention and that excessive concern among families is unnecessary.
(© 2024. The Author(s).)
Databáze: MEDLINE
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