Metabolic regulation of the immune system in health and diseases: mechanisms and interventions.

Autor: Hu T; West China School of clinical medical, West China Second University Hospital, Sichuan University, Chengdu, China.; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Infectious and Liver Diseases, Institution of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China., Liu CH; West China School of clinical medical, West China Second University Hospital, Sichuan University, Chengdu, China.; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Infectious and Liver Diseases, Institution of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China., Lei M; West China School of clinical medical, West China Second University Hospital, Sichuan University, Chengdu, China.; National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.; State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China., Zeng Q; West China School of clinical medical, West China Second University Hospital, Sichuan University, Chengdu, China.; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.; Laboratory of Infectious and Liver Diseases, Institution of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China., Li L; Division of Renal and endocrinology, Qin Huang Hospital, Xi'an, China., Tang H; Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China. tanghong6198@wchscu.cn.; Laboratory of Infectious and Liver Diseases, Institution of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China. tanghong6198@wchscu.cn.; State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China. tanghong6198@wchscu.cn., Zhang N; West China School of clinical medical, West China Second University Hospital, Sichuan University, Chengdu, China. nannan7687@scu.edu.cn.; National Center for Birth Defect Monitoring, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. nannan7687@scu.edu.cn.; State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China. nannan7687@scu.edu.cn.
Jazyk: angličtina
Zdroj: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2024 Oct 09; Vol. 9 (1), pp. 268. Date of Electronic Publication: 2024 Oct 09.
DOI: 10.1038/s41392-024-01954-6
Abstrakt: Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathogenesis and progression of numerous diseases, such as cancers, autoimmune diseases and metabolic diseases. The concept of immunometabolism was introduced over a decade ago to elucidate the intricate interplay between metabolism and immunity. The definition of immunometabolism has expanded from chronic low-grade inflammation in metabolic diseases to metabolic reprogramming of immune cells in various diseases. With immunometabolism being proposed and developed, the metabolic regulation of the immune system can be gradually summarized and becomes more and more clearer. In the context of many diseases including cancer, autoimmune diseases, metabolic diseases, and many other disease, metabolic reprogramming occurs in immune cells inducing proinflammatory or anti-inflammatory effects. The phenotypic and functional changes of immune cells caused by metabolic regulation further affect and development of diseases. Based on experimental results, targeting cellular metabolism of immune cells becomes a promising therapy. In this review, we focus on immune cells to introduce their metabolic pathways and metabolic reprogramming, and summarize how these metabolic pathways affect immune effects in the context of diseases. We thoroughly explore targets and treatments based on immunometabolism in existing studies. The challenges of translating experimental results into clinical applications in the field of immunometabolism are also summarized. We believe that a better understanding of immune regulation in health and diseases will improve the management of most diseases.
(© 2024. The Author(s).)
Databáze: MEDLINE
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