Dose and timing effects of caffeine on subsequent sleep: A randomised clinical crossover trial.

Autor:	Gardiner CL; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia., Weakley J; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia.; Carnegie Applied Rugby Research (CARR) Centre, Institute of Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UK., Burke LM; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia., Fernandez F; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia., Johnston RD; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia.; Carnegie Applied Rugby Research (CARR) Centre, Institute of Sport, Physical Activity and Leisure, Leeds Beckett University, Leeds, UK., Leota J; School of Psychological Sciences, Monash University, Melbourne, Australia.; Turner Institute for Brain and Mental Health, Monash University, Melbourne Australia., Russell S; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia., Munteanu G; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia., Townshend A; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia., Halson SL; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.; Sports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre, Australian Catholic University, Brisbane, Australia.
Jazyk:	angličtina
Zdroj:	Sleep [Sleep] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.
DOI:	10.1093/sleep/zsae230
Abstrakt:	Study Objectives: To investigate the effect of a typical dose of caffeine and a high dose of caffeine consumed in the morning, afternoon, and evening on subsequent sleep. Methods: Using a placebo-controlled, double-blind, randomised crossover design, 23 males (25.3±5.0 years) with a moderate habitual caffeine intake (<300mg∙day-1) completed seven conditions: placebo, and 100 and 400mg of caffeine consumed 12, eight, and four hours prior to bedtime, with a 48-hour washout. In-home partial polysomnography and sleep diaries were used to assess sleep. Linear mixed models estimated the effect of each condition. Results: No significant effect on objective or subjective sleep occurred with the 100mg dose of caffeine compared to the placebo (p>0.05) but significant effects occurred with the 400mg dose (p<0.05). Significant delays in sleep initiation and alterations to sleep architecture were observed when 400mg was consumed within 12 hours of bedtime (p<0.05), and significantly greater sleep fragmentation occurred when 400mg was consumed within eight hours of bedtime (p<0.05). Additionally, perceived sleep quality was significantly reduced when 400mg was consumed four hours prior to bedtime (-34.02%, p=.006) but not at eight or 12 hours. Conclusions: A 100mg dose of caffeine can be consumed up to four hours prior to bedtime, but 400mg may negatively impact sleep when consumed as one dose within 12 hours of bedtime, with the adverse influence on sleep increasing the closer consumption occurs to bedtime. The discrepancy between objective and subjective sleep quality suggests individuals may have difficulty accurately perceiving the influence of caffeine on sleep quality. (© The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.)
Databáze:	MEDLINE
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