Demographics and Clinical Features Associated with Abnormal Small Bowel Motility in Systemic Sclerosis.

Autor:	Cheah JX; Department of Medicine, University of California-Los Angeles, Los Angeles, CA., Perin J; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD., Hughes M; Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, UK.; Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK., Mecoli CA; Johns Hopkins University, Department of Medicine, Division of Rheumatology, Baltimore, MD., Paik JJ; Johns Hopkins University, Department of Medicine, Division of Rheumatology, Baltimore, MD., Hummers LK; Johns Hopkins University, Department of Medicine, Division of Rheumatology, Baltimore, MD., Shah AA; Johns Hopkins University, Department of Medicine, Division of Rheumatology, Baltimore, MD., McMahan ZH; Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.
DOI:	10.1093/rheumatology/keae542
Abstrakt:	Objective: The small bowel is affected in up to 50% of systemic sclerosis (SSc) patients, and some patients experience severe complications. Our aim was to use specific statistical methods to compare demographic and clinical features of SSc patients with and without abnormal small bowel to better characterize patients at risk for this complication. Methods: SSc patients with gastrointestinal symptoms were prospectively enrolled and underwent a scintigraphy-based whole gut transit (WGT) study. A cross-sectional analysis was performed comparing clinical features between patients with and without abnormal small bowel transit by WGT. Univariate logistic regression models and multivariable models were used to examine the relationship between clinical features and abnormal small bowel transit. Results: Of 130 patients enrolled in this study, 22 had abnormal small bowel transit. SSc patients with abnormal small bowel transit were more likely to be male [Odds Ratio(OR)=3.70, Confidence Interval(CI) 1.07-12.50, p= 0.038], and have more severe cardiac involvement (OR = 3.98, CI 1.10-14.38, p= 0.035), while they were less likely to have sicca symptoms (OR = 0.30, CI 0.10-0.94, p= 0.039). In multivariable analyses, sicca symptoms (OR = 0.28, CI 0.08-0.96, p= 0.043) remained negatively associated with abnormal small bowel transit. Additionally, SSc patients with abnormal small bowel transit had higher mortality than patients with normal small bowel transit [Hazard ratio(HR)=4.57, CI 1.58-13.24, p= 0.005]. Conclusions: These findings suggest that patients with abnormal small bowel transit in SSc are more likely to be male, have more severe cardiac involvement, higher mortality, and less sicca symptoms. Recognizing this patient subgroup is essential for risk stratification and optimizing clinical care. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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