Estimating the force of infection of four dengue serotypes from serological studies in two regions of Vietnam.

Autor: Phuong HT; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Vy NHT; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam., Thanh NTL; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam., Tan M; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., de Bruin E; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Koopmans M; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Boni MF; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands.; Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, Unites States of America., Clapham HE; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Oct 07; Vol. 18 (10), pp. e0012568. Date of Electronic Publication: 2024 Oct 07.
DOI: 10.1371/journal.pntd.0012568
Abstrakt: Dengue is endemic in Vietnam with circulation of all four serotypes (DENV1-4) all year-round. It is hard to estimate the disease's true serotype-specific transmission patterns from cases due to its high asymptomatic rate, low reporting rate and complex immunity and transmission dynamics. Seroprevalence studies have been used to great effect for understanding patterns of dengue transmission. We tested 991 population serum samples (ages 1-30 years, collected 2013 to 2017), 531 from Ho Chi Minh City and 460 from Khanh Hoa in Vietnam, using a flavivirus protein microarray assay. By applying our previously developed inference framework to the antibody profiles from this assay, we can (1) determine proportions of a population that have not been infected or infected, once, or more than once, and (2) infer the infecting serotype in those infected once. With these data, we then use mathematical models to estimate the force of infection (FOI) for all four DENV serotypes in HCMC and KH over 35 years up to 2017. Models with time-varying or serotype-specific DENV FOI assumptions fit the data better than constant FOI. Annual dengue FOI ranged from 0.005 (95%CI: 0.003-0.008) to 0.201 (95%CI: 0.174-0.228). FOI varied across serotypes, higher for DENV1 (95%CI: 0.033-0.048) and DENV2 (95%CI: 0.018-0.039) than DENV3 (95%CI: 0.007-0.010) and DENV4 (95%CI: 0.010-0.016). The use of the PMA on serial age-stratified cross-sectional samples increases the amount of information on transmission and population immunity, and should be considered for future dengue serological surveys, particularly to understand population immunity given vaccines with differential efficacy against serotypes, however, there remains limits to what can be inferred even using this assay.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Phuong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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