Mpox Recurrence and Tecovirimat Resistance in a Patient With Advanced Human Immunodeficiency Virus Disease.

Autor: Griffith DC; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Fall A; Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland, USA., Carter M; Johns Hopkins Regional Physicians, Baltimore, Maryland, USA., Traut CC; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Sop J; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Hansoti B; Department of Emergency Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA., Gebo KA; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Mostafa HH; Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland, USA., Blankson JN; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Jazyk: angličtina
Zdroj: Open forum infectious diseases [Open Forum Infect Dis] 2024 Sep 23; Vol. 11 (10), pp. ofae549. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI: 10.1093/ofid/ofae549
Abstrakt: We present a case of mpox recurrence in a transgender woman with AIDS. Her recurrent lesions required several courses of antiviral therapy over a 5-month period and her monkeypox viral genome was subsequently noted to have tecovirimat resistance mutations. Interestingly, she developed a robust orthopoxvirus-specific T-cell response.
Competing Interests: Potential conflicts of interest. All authors: No reported conflicts.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje