Gamma-aminobutyric acid in the honey bee mushroom bodies - is inhibition the wellspring of plasticity?

Autor: Fahrbach SE; Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA. Electronic address: fahrbach@wfu.edu.
Jazyk: angličtina
Zdroj: Current opinion in insect science [Curr Opin Insect Sci] 2024 Dec; Vol. 66, pp. 101278. Date of Electronic Publication: 2024 Oct 05.
DOI: 10.1016/j.cois.2024.101278
Abstrakt: Structural plasticity is the hallmark of the protocerebral mushroom bodies of adult insects. This plasticity is especially well studied in social hymenopterans. In adult worker honey bees, phenomena such as increased neuropil volume, increased dendritic branching, and changes in the details of synaptic microcircuitry are associated with both the onset of foraging and the accumulation of foraging experience. Prior models of the drivers of these changes have focused on differences between the sensory environment of the hive and the world outside the hive, leading to enhanced excitatory (cholinergic) inputs to the intrinsic neurons of the mushroom bodies (Kenyon cells). This article proposes experimental and bioinformatics-based approaches for the exploration of a role for changes in the inhibitory (GABAergic) innervation of the mushroom bodies as a driver of sensitive periods for structural plasticity in the honey bee brain.
Competing Interests: Declaration of Competing Interest The author has no financial or personal relationships that inappropriately influence or bias the content of the paper.
(Copyright © 2024 The Author. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: