Emerging Orchestrator of Ecological Adaptation: m 6 A Regulation of Post-Transcriptional Mechanisms.

Autor: Ahi EP; Organismal and Evolutionary Biology Research Programme, University of Helsinki, Helsinki, Finland., Singh P; Institute of Ecology and Evolution, University of Bern, Bern, Switzerland.; Swiss Federal Institute of Aquatic Science and Technology (EAWAG), Kastanienbaum, Switzerland.
Jazyk: angličtina
Zdroj: Molecular ecology [Mol Ecol] 2024 Oct 05, pp. e17545. Date of Electronic Publication: 2024 Oct 05.
DOI: 10.1111/mec.17545
Abstrakt: Genetic mechanisms have been at the forefront of our exploration into the substrate of adaptive evolution and phenotypic diversification. However, genetic variation only accounts for a fraction of phenotypic variation. In the last decade, the significance of RNA modification mechanisms has become more apparent in the context of organismal adaptation to rapidly changing environments. RNA m 6 A methylation, the most abundant form of RNA modification, is emerging as a potentially significant player in various biological processes. Despite its fundamental function to regulate other major post-transcriptional mechanisms such as microRNA and alternative splicing, its role in ecology and evolution has been understudied. This review highlights the potential importance of m 6 A RNA methylation in ecological adaptation, emphasising the need for further research, especially in natural systems. We focus on how m 6 A not only affects mRNA fate but also influences miRNA-mediated gene regulation and alternative splicing, potentially contributing to organismal adaptation. The aim of this review is to synthesise key background information to enhance our understanding of m 6 A mechanisms driving species survival in dynamic environments and motivate future research into the dynamics of adaptive RNA methylation.
(© 2024 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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