An integrated active case detection and management of skin NTDs in yaws endemic health districts in Cameroon, Côte d'Ivoire and Ghana.

Autor: Tchatchouang S; Centre Pasteur du Cameroun, Yaoundé, Cameroon., Basing LA; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana., Kouadio-Aboh H; Institut Pasteur de Cote d'Ivoire, Abidjan, Lagunes, Côte d'Ivoire.; National Program of African Trypanosomiasis Elimination, Abidjan, Côte d'Ivoire., Handley BL; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom., G-Beiras C; Skin Neglected Tropical Diseases and Sexually Transmitted Infections section, Hospital Universitari Germans Trías i Pujol; Fight Infectious Diseases Foundation,Badalona, Barcelona, Spain.; Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain., Amanor I; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana., Ndzomo P; Centre Pasteur du Cameroun, Yaoundé, Cameroon., Bakheit M; Mast Diagnostica GmbH, Reinfeld, Germany., Becherer L; Laboratory for MEMS Applications, IMTEK-Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany., Knauf S; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.; Professorship for One Health/International Animal Health, Faculty of Veterinary Medicine, Justus Liebig University, Giessen, Germany., Müller C; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Njih-Tabah E; National Buruli Ulcer, Leprosy, Yaws and Leishmaniasis Control Program, Ministry of Public Health, Yaounde, Centre Region, Cameroon.; Public Health & Epidemiology, University of Dschang, Dschang, West Region, Cameroon., Njamnshi T; National Buruli Ulcer, Leprosy, Yaws and Leishmaniasis Control Program, Ministry of Public Health, Yaounde, Centre Region, Cameroon., Crucitti T; Experimental Bacteriology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar., Borst N; Laboratory for MEMS Applications, IMTEK-Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany.; Hahn-Schickard, Freiburg, Germany., Lüert S; Institute of International Animal Health/One Health, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany., Frischmann S; Mast Diagnostica GmbH, Reinfeld, Germany., Gmoser H; Laboratory for MEMS Applications, IMTEK-Department of Microsystems Engineering, University of Freiburg, Freiburg, Germany., Landmann E; Mast Diagnostica GmbH, Reinfeld, Germany., Sylla A; Institut Pasteur de Cote d'Ivoire, Abidjan, Lagunes, Côte d'Ivoire., Kouamé-Sina MS; Institut Pasteur de Cote d'Ivoire, Abidjan, Lagunes, Côte d'Ivoire., Arhinful D; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana., Awondo P; Centre Pasteur du Cameroun, Yaoundé, Cameroon., Menguena G; Centre Pasteur du Cameroun, Yaoundé, Cameroon., Harding-Esch EM; Clinical Research Department, London School of Hygiene & Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom., Tano A; Institut Pasteur de Cote d'Ivoire, Abidjan, Lagunes, Côte d'Ivoire., Kaloga M; Programme National de Lutte contre l'Ulcère de Buruli, Abidjan, Côte d'Ivoire., Koffi-Aboa P; Programme National de Lutte contre l'Ulcère de Buruli, Abidjan, Côte d'Ivoire., Konama-Kotey N; National Yaws Eradication Program, Ghana Health Service, Accra, Ghana., Mitjà O; Skin Neglected Tropical Diseases and Sexually Transmitted Infections section, Hospital Universitari Germans Trías i Pujol; Fight Infectious Diseases Foundation,Badalona, Barcelona, Spain.; Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Barcelona, Spain., Eyangoh S; Centre Pasteur du Cameroun, Yaoundé, Cameroon., Kwasi-Addo K; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana., Ngazoa-Kakou S; Institut Pasteur de Cote d'Ivoire, Abidjan, Lagunes, Côte d'Ivoire., Marks M; Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.; Clinical Research Department, London School of Hygiene & Tropical Medicine, Faculty of Infectious and Tropical Diseases, London, United Kingdom.; Hospital for Tropical Diseases, London, United Kingdom.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Oct 04; Vol. 18 (10), pp. e0011790. Date of Electronic Publication: 2024 Oct 04 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0011790
Abstrakt: Background: Integrated approaches to mapping skin Neglected Tropical Diseases (NTDs) may be cost-effective way to guide decisions on resource mobilization. Pilot studies have been carried out, but large-scale data covering multiple countries endemic for skin NTDs are lacking. Within the LAMP4YAWS project, we collected integrated data on the burden of multiple skin NTDs.
Methods: From March 2021 to March 2023, integrated case searches for yaws alongside other skin conditions were performed in endemic health districts of yaws in Cameroon, Côte d'Ivoire, and Ghana. Integrated activities included training, social mobilization and active case detection. Initial screening involved a brief clinical examination of participants to determine if any skin conditions were suspected. Cases of skin NTDs were then referred to a health facility for appropriate management.
Results: Overall 61,080 individuals screened, 11,387 (18.6%) had skin lesions. The majority of individuals (>90%) examined were children aged 15 years old and under. The proportion of serologically confirmed yaws cases was 8.6% (18/210) in Cameroon, 6.8% (84/1232) in Côte d'Ivoire, and 26.8% (440/1643) in Ghana. Other skin conditions based on clinical examination included: scabies, Buruli ulcer, leprosy, lymphatic filariasis (lymphoedema and hydrocele), tungiasis, and fungal infections. The most common conditions were scabies and superficial fungal infections. In Cameroon, scabies and superficial fungal infections accounted for 5.1% (214/4204) and 88.7% (3730/4204) respectively, 25.2% (1285/5095) and 50.4% (2567/5095) in Côte d'Ivoire. In Ghana, 20% (419/2090) of individuals had scabies but superficial fungal infections were not routinely recorded and were reported in only 1.3% (28/2090). Other skin NTDs were less common across all three countries.
Conclusion: This study confirms that integrated screening allows simultaneous detection of multiple skin NTDs, maximising use of scarce resources.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Tchatchouang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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