Sea cucumber-derived extract can protect skin cells from oxidative DNA damage and mitochondrial degradation, and promote wound healing.

Autor: Mazumder B; Cambridge Infinitus Research Centre, University of Cambridge, Cambridge CB3 0AS, UK; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Lu M; Cambridge Infinitus Research Centre, University of Cambridge, Cambridge CB3 0AS, UK; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK; Current address: Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China., Rahmoune H; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Fernandez-Villegas A; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Ward E; Cambridge Infinitus Research Centre, University of Cambridge, Cambridge CB3 0AS, UK; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Wang M; School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China., Ren J; School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China., Yu Y; Infinitus (China) Company Ltd., Guangzhou 510623, China., Zhang T; Infinitus (China) Company Ltd., Guangzhou 510623, China., Liang M; Infinitus (China) Company Ltd., Guangzhou 510623, China., Li W; Infinitus (China) Company Ltd., Guangzhou 510623, China., Läubli NF; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Kaminski CF; Cambridge Infinitus Research Centre, University of Cambridge, Cambridge CB3 0AS, UK; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK., Kaminski Schierle GS; Cambridge Infinitus Research Centre, University of Cambridge, Cambridge CB3 0AS, UK; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK. Electronic address: gsk20@cam.ac.uk.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Nov; Vol. 180, pp. 117466. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1016/j.biopha.2024.117466
Abstrakt: Our skin serves as the primary barrier against external environmental insults, the latter of which can cause oxidative stress within cells, while various bioactive peptides sourced from natural resources hold promise in protecting cells against such oxidative stress. In this study, we investigate the efficacy of a low molecular weight extract from the sea cucumber Apostichopus japonicus, denoted as Sample-P, in facilitating cell migration and wound healing under oxidative stress conditions in skin cells. The naturally derived compound is a highly complex mix of peptides exhibiting antioxidative properties, as highlighted through liquid chromatography-mass spectrometry peptide screening and an in vitro antioxidant assay. Our results demonstrate that Sample-P is capable of promoting cell migration while preventing severe stress responses such as visible through mTOR expression. To further identify the molecular pathways underpinning the overall protective mechanism of Sample-P, we have utilised a proteomics approach. Our data reveal that Sample-P regulates protein expression associated with ribosomal pathways, glycolysis/gluconeogenesis and protein processing in the endoplasmic reticulum (ER), which help in preserving DNA integrity and safeguarding cellular organelles, such as mitochondria and the ER, under oxidative stress conditions in skin cells. In summary, in the presence of H 2 O 2 , Sample-P exhibits antioxidative properties at both molecular and cellular levels, rendering it a promising candidate for topical skin treatment to wound healing and to address age-related skin conditions.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yi Yu, Ting Zhan, Ming Liang and Wenzhi Li work for Infinitus (China) Company Ltd.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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