Examining relationships among NODDI indices of white matter structure in prefrontal cortical-thalamic-striatal circuitry and OCD symptomatology.

Autor: Lima Santos JP; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. limasantosjp2@upmc.edu., Versace A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.; Magnetic Resonance Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Arora M; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Bertocci MA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Chase HW; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Skeba A; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Graur S; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Bonar L; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA., Maffei C; Department of Radiology, McLean Hospital, Harvard Medical School, Boston, MA, USA., Yendiki A; Department of Radiology, McLean Hospital, Harvard Medical School, Boston, MA, USA., Rasmussen SA; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA., Haber SN; Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA.; School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA., Phillips ML; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Translational psychiatry [Transl Psychiatry] 2024 Oct 02; Vol. 14 (1), pp. 410. Date of Electronic Publication: 2024 Oct 02.
DOI: 10.1038/s41398-024-03101-9
Abstrakt: Obsessive-compulsive disorder is a psychiatric disorder characterized by intrusive thoughts and repetitive behaviors. There are two prominent features: Harm Avoidance (HA) and Incompleteness (INC). Previous resting-state studies reported abnormally elevated connectivity between prefrontal cortical (PFC) and subcortical regions (thalamus, striatum) in OCD participants. Yet, little is known about the white matter (WM) structural abnormalities in these connections. Using brain parcellation and segmentation, whole brain tractography, and Neurite Orientation Dispersion and Density Imaging (NODDI), we aimed to characterize WM structural abnormalities in OCD vs. healthy controls and determine the extent to which NODDI indices of these connections were associated with subthreshold-threshold HA, INC and overall OCD symptom severity across all participants. Four PFC regions were segmented: ventral medial (vmPFC), ventrolateral (vlPFC), dorsomedial (dmPFC), and dorsolateral (dlPFC). NODDI Neurite Density (NDI) and Orientation Dispersion (ODI) indices of WM structure were extracted from connections between these PFC regions and the thalamus (42 OCD, 44 healthy controls, mean age[SD] = 23.65[4.25]y, 63.9% female) and striatum (38 OCD, 41 healthy controls, mean age[SD] = 23.59[4.27]y, 64.5% female). Multivariate analyses of covariance revealed no between-group differences in these indices. Multivariate regression models revealed that greater NDI in vmPFC-thalamus, greater NDI and ODI in vmPFC-striatum, and greater NDI in dmPFC-thalamus connections were associated with greater INC severity (Q ≤ 0.032). These findings highlight the utility of NODDI in the examination of WM structure in OCD, provide valuable insights into specific WM alterations underlying dimensional INC, and can facilitate the development of customized treatments for OCD individuals with treatment-resistant symptoms.
(© 2024. The Author(s).)
Databáze: MEDLINE
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