Trajectory of Cognitive Decline Before and After Stroke in 14 Population Cohorts.

Autor:	Lo JW; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia., Crawford JD; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia., Lipnicki DM; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia., Lipton RB; Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York., Katz MJ; Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York., Preux PM; Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France., Guerchet M; Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.; Laboratory of Chronic and Neurological Diseases Epidemiology, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin., d'Orsi E; Federal University of Santa Catarina, Trindade University Campus, Florianópolis, Santa Catarina, Brazil., Quialheiro A; IA&Saúde-The Artificial Intelligence and Health Research Unit, Polytechnic University of Health, CESPU, Portugal., Rech CR; Department of Physical Education, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil., Ritchie K; Inserm U1061: Neuropsychiatrie Hôpital La Colombière, BP34493, Montpellier, France., Skoog I; Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden., Najar J; Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Psychotic Disorders, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.; Section Genomics of Neurdegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands., Sterner TR; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, Centre for Ageing and Health, University of Gothenburg, Gothenburg, Sweden., Rolandi E; Golgi Cenci Foundation, Abbiategrasso, Italy.; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy., Davin A; Golgi Cenci Foundation, Abbiategrasso, Italy., Rossi M; Golgi Cenci Foundation, Abbiategrasso, Italy., Riedel-Heller SG; Faculty of Medicine, Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Pabst A; Faculty of Medicine, Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Röhr S; Faculty of Medicine, Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.; School of Psychology, Massey University, Albany Campus, Auckland, Aotearoa, New Zealand.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Ganguli M; Departments of Psychiatry, Neurology, and Epidemiology, School of Medicine and School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Jacobsen E; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Snitz BE; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Anstey KJ; Ageing Futures Institute, University of New South Wales, Sydney, Australia.; Neuroscience Research Australia, Sydney, Australia.; School of Psychology, University of New South Wales, Sydney, Australia., Aiello AE; Department of Epidemiology and Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, New York., Brodaty H; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia., Kochan NA; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia., Chen YC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Master Program of Statistics, National Taiwan University, Taipei, Taiwan., Chen JH; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Sanchez-Juan P; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, 28031, Madrid, Spain., Del Ser T; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, 28031, Madrid, Spain., Valentí M; Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, 28031, Madrid, Spain., Lobo A; Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain., De-la-Cámara C; Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain.; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain., Lobo E; Department of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.; Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain.; Department of Preventive Medicine and Public Health, Universidad de Zaragoza, Zaragoza, Spain., Sachdev PS; Centre for Healthy Brain Ageing, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Jazyk:	angličtina
Zdroj:	JAMA network open [JAMA Netw Open] 2024 Oct 01; Vol. 7 (10), pp. e2437133. Date of Electronic Publication: 2024 Oct 01.
DOI:	10.1001/jamanetworkopen.2024.37133
Abstrakt:	Importance: Poststroke cognitive impairment is common, but the cognitive trajectory following a first stroke, relative to prestroke cognitive function, remains unclear. Objective: To map the trajectory of cognitive function before any stroke and after stroke in global cognition and in 4 cognitive domains, as well as to compare the cognitive trajectory prestroke in stroke survivors with the trajectory of individuals without incident stroke over follow-up. Design, Setting, and Participants: The study used harmonized and pooled data from 14 population-based cohort studies included in the Cohort Studies of Memory in an International Consortium collaboration. These studies were conducted from 1993 to 2019 across 11 countries among community-dwelling older adults without a history of stroke or dementia. For this study, linear mixed-effects models were used to estimate trajectories of cognitive function poststroke relative to a stroke-free cognitive trajectory. The full model adjusted for demographic and vascular risk factors. Data were analyzed from July 2022 to March 2024. Exposure: Incident stroke. Main Outcomes and Measures: The primary outcome was global cognition, defined as the standardized average of 4 cognitive domains (language, memory, processing speed, and executive function). Cognitive domain scores were formed by selecting the most commonly administered test within each domain and standardizing the scores. Results: The study included 20 860 participants (12 261 [58.8%] female) with a mean (SD) age of 72.9 (8.0) years and follow-up of 7.51 (4.2) years. Incident stroke was associated with a substantial acute decline in global cognition (-0.25 SD; 95% CI, -0.33 to -0.17 SD), the Mini-Mental State Examination, and all cognitive domains (ranging from -0.17 SD to -0.22 SD), as well as accelerated decline in global cognition (-0.038 SD per year; 95% CI, -0.057 to -0.019 SD per year) and all domains except memory (ranging from -0.020 to -0.055 SD per year), relative to a stroke-free cognitive trajectory. There was no significant difference in prestroke slope in stroke survivors compared with the rate of decline in individuals without stroke in all cognitive measures. The mean rate of decline without a previous stroke was -0.049 SD per year (95% CI, -0.051 to -0.047 SD) in global cognition. Conclusions and Relevance: In this cohort study using pooled data from 14 cohorts, incident stroke was associated with acute and accelerated long-term cognitive decline in older stroke survivors.
Databáze:	MEDLINE
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