Effects of mixed nuts as part of a Brazilian Cardioprotective diet on LDL-cholesterol in adult patients after myocardial infarction: a multicenter randomized controlled clinical trial.

Autor: Bersch-Ferreira ÂC; Department of Education and Research, BP - Beneficência Portuguesa de São Paulo, São Paulo, SP, Brazil.; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., Weschenfelder C; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Vieira Machado RH; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., Nakagawa Santos RH; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., Riley TM; Pennington Biomedical Research Center, Baton Rouge, LA, United States of America., da Silva LR; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., Miyada DHK; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., Sady ERR; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., de Abreu-Silva EO; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil.; Master`S Program in Clinical Research, Dresden International University, Dresden, Germany., Laranjeira LN; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., de Quadros AS; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Dos Santos JL; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia Do Rio Grande Do Sul, Porto Alegre, RS, Brazil., Souza GC; Graduation Program in Food, Nutrition and Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Parahiba SM; Graduation Program in Food, Nutrition and Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil., Fayh APT; PesqClin Lab, Onofre Lopes University Hospital, Brazilian Company of Hospital Services (EBSERH), Universidade Federal Do Rio Grande Do Norte, Natal, RN, Brazil., Bezerra DS; Faculty of Health Science of Trairi, Universidade Federal Do Rio Grande Do Norte (FACISA-UFRN), Santa Cruz, RN, Brazil., Carvalho APPF; Hypertension Unit-NIPEE, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., Machado MMA; Hypertension Unit-NIPEE, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil., Vasconcelos SML; Faculty of Nutrition, Universidade Federal de Alagoas (UFAL), Maceió, AL, Brazil., Santos MVR; Faculty of Nutrition, Universidade Federal de Alagoas (UFAL), Maceió, AL, Brazil., de Figueiredo Neto JA; Department of Cardiology, Universidade Federal Do Maranhão (UFMA), São Luiz, MA, Brazil., Dias LPP; Department of Cardiology, Universidade Federal Do Maranhão (UFMA), São Luiz, MA, Brazil., Zaina Nagano FE; Complexo Hospital de Clínicas, Universidade Federal Do Paraná (HU-UFPR), Curitiba, PR, Brazil., de Almeida CCP; Graduation Program in Internal Medicine and Health Sciences, Universidade Federal Do Paraná (UFPR), Curitiba, PR, Brazil., Moreira ASB; Instituto Nacional de Cardiologia (INC), Rio de Janeiro, RJ, Brazil., de Oliveira RD; Instituto Nacional de Cardiologia (INC), Rio de Janeiro, RJ, Brazil., Rogero MM; Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, SP, Brazil., Sampaio GR; Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, SP, Brazil., da Silva Torres EAF; Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, SP, Brazil., Weber B; PROADI-SUS Office, Real e Benemérita Associação Portuguesa de Beneficência, São Paulo, SP, Brazil., Cavalcanti AB; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil., Marcadenti A; Hcor Research Institute, 200 Desembargador Eliseu Guilherme, 8th Floor, São Paulo, SP, Zip Code 04004-030, Brazil. marcadenti.aline@gmail.com.; Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. marcadenti.aline@gmail.com.
Jazyk: angličtina
Zdroj: Nutrition journal [Nutr J] 2024 Oct 01; Vol. 23 (1), pp. 118. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1186/s12937-024-01020-5
Abstrakt: Background: Nuts consumption is related to cardioprotective effects on primary cardiovascular prevention, but studies conducted in secondary prevention are small, scarce and controversial. The objective of this trial was to evaluate the effects of a regional and sustainable cardioprotective diet added or not with an affordable mixed nuts on cardiometabolic features in patients with previous myocardial infarction.
Methods: DICA-NUTS study is a national, multi-center, and superiority-parallel randomized clinical trial. Males and females over 40 years old diagnosed with previous myocardial infarction in the last 2 to 6 months were included. Patients were allocated into two groups: the Brazilian Cardioprotective diet (DICA Br) supplemented with 30 g/day of mixed nuts (10 g of peanuts; 10 g of cashew; 10 g of Brazil nuts) (intervention group, n = 193); or only DICA Br prescription (control group, n = 195). The primary outcome was low-density lipoprotein cholesterol means (in mg/dL) after 16 weeks. Secondary outcomes were other lipid biomarkers, glycemic and anthropometric data and diet quality.
Results: After adjustment for baseline values, participating study site, time since myocardial infarction and statin treatment regimen (high potency, moderate and low potency/no statins), no significant difference was found between the groups in low-density lipoprotein cholesterol concentrations (intervention-control difference: 3.48 mg/dL [-3.45 to 10.41], P = 0.32). Both groups improved their overall diet quality at the end of the study without differences between them after 16 weeks (intervention-control difference: 1.05 (-0.9 to 2.99); P = 0.29). Other lipids, glycemic profile and anthropometrics were also not different between study groups at the end of the study.
Conclusion: Adding 30 g/day of mixed nuts to the DICA Br for 16 weeks did not change lipid, glycemic and anthropometric features in the post-myocardial infarction setting.
Trial Registration: This study is registered on ClinicalTrials.gov website under number NCT03728127 and its World Health Organization Universal Trial Number (WHO-UTN) is U1111-1259-8105.
(© 2024. The Author(s).)
Databáze: MEDLINE
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