Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions.

Autor: Barton K; Department of Radiology, Oregon Health & Science University, Portland, OR, USA. barton.katherine@gmail.com.; Department of Diagnostic Radiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Mail Code L340, Portland, OR, 97239, USA. barton.katherine@gmail.com., Yellowman RD; University of Minnesota Medical School, Minneapolis, MN, USA., Holm T; Department of Radiology, University of Minnesota, Masonic Children's Hospital, Minneapolis, MN, USA., Beaulieu F; Department of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zuckerberg G; Department of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gwal K; Department of Radiology, Nemours Children's Hospital, Wilmington, DE, USA., Setty BN; Department of Radiology, Boston University, Boston, MA, USA., Janitz E; Department of Radiology, Akron Children's Hospital, Akron, OH, USA., Hwang M; Department of Radiology, University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: Pediatric radiology [Pediatr Radiol] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.
DOI: 10.1007/s00247-024-06066-5
Abstrakt: Literature examining possible deleterious effects of anesthesia exposure on the developing brain has increased substantially over the past 30 years. Initial concerning findings in animal models, both rodents and non-human primates, prompted increasingly thorough examinations in humans, including randomized controlled trials. This review will provide a concise overview of what we know about anesthesia and the developing brain: the background in animal studies, the most robust results we have in humans, and the work yet to be done. This is particularly relevant to a pediatric radiology audience because we have the unique opportunity to modify anesthesia exposure during imaging through innovation.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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